Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib

Here we report a case of an 11-year-old girl with an inoperable tumor in the optic chiasm/hypothalamus, who experienced several tumor progressions despite three lines of chemotherapy treatment. Routine clinical examination classified the tumor as a BRAF-negative pilocytic astrocytoma. Copy-number va...

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Detalles Bibliográficos
Autores principales: Deland, Lily, Keane, Simon, Olsson Bontell, Thomas, Sjögren, Helene, Fagman, Henrik, Øra, Ingrid, De La Cuesta, Esther, Tisell, Magnus, Nilsson, Jonas A, Ejeskär, Katarina, Sabel, Magnus, Abel, Frida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Bedside-to-Bench Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043191/
https://www.ncbi.nlm.nih.gov/pubmed/33820494
http://dx.doi.org/10.1080/15384047.2021.1899573

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