Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines

[Image: see text] The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history. A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase N1-methylpseudouridine (m1Ψ) to increase their e...

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Autores principales: Nance, Kellie D., Meier, Jordan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043204/
https://www.ncbi.nlm.nih.gov/pubmed/34075344
http://dx.doi.org/10.1021/acscentsci.1c00197
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author Nance, Kellie D.
Meier, Jordan L.
author_facet Nance, Kellie D.
Meier, Jordan L.
author_sort Nance, Kellie D.
collection PubMed
description [Image: see text] The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history. A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase N1-methylpseudouridine (m1Ψ) to increase their effectiveness. In this Outlook, we summarize the development and function of m1Ψ in synthetic mRNAs. By demystifying how a novel element within these medicines works, we aim to foster understanding and highlight future opportunities for chemical innovation.
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spelling pubmed-80432042021-04-13 Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines Nance, Kellie D. Meier, Jordan L. ACS Cent Sci [Image: see text] The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history. A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase N1-methylpseudouridine (m1Ψ) to increase their effectiveness. In this Outlook, we summarize the development and function of m1Ψ in synthetic mRNAs. By demystifying how a novel element within these medicines works, we aim to foster understanding and highlight future opportunities for chemical innovation. American Chemical Society 2021-04-06 2021-05-26 /pmc/articles/PMC8043204/ /pubmed/34075344 http://dx.doi.org/10.1021/acscentsci.1c00197 Text en Not subject to U.S. Copyright. Published 2021 by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Nance, Kellie D.
Meier, Jordan L.
Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines
title Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines
title_full Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines
title_fullStr Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines
title_full_unstemmed Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines
title_short Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines
title_sort modifications in an emergency: the role of n1-methylpseudouridine in covid-19 vaccines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043204/
https://www.ncbi.nlm.nih.gov/pubmed/34075344
http://dx.doi.org/10.1021/acscentsci.1c00197
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