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Breast lesion detection through MammoWave device: Empirical detection capability assessment of microwave images’ parameters

MammoWave is a microwave imaging device for breast lesions detection, which operates using two (azimuthally rotating) antennas without any matching liquid. Images, subsequently obtained by resorting to Huygens Principle, are intensity maps, representing the homogeneity of tissues’ dielectric propert...

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Autores principales: Sani, Lorenzo, Vispa, Alessandro, Loretoni, Riccardo, Duranti, Michele, Ghavami, Navid, Alvarez Sánchez-Bayuela, Daniel, Caschera, Stefano, Paoli, Martina, Bigotti, Alessandra, Badia, Mario, Scorsipa, Michele, Raspa, Giovanni, Ghavami, Mohammad, Tiberi, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043413/
https://www.ncbi.nlm.nih.gov/pubmed/33848318
http://dx.doi.org/10.1371/journal.pone.0250005
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author Sani, Lorenzo
Vispa, Alessandro
Loretoni, Riccardo
Duranti, Michele
Ghavami, Navid
Alvarez Sánchez-Bayuela, Daniel
Caschera, Stefano
Paoli, Martina
Bigotti, Alessandra
Badia, Mario
Scorsipa, Michele
Raspa, Giovanni
Ghavami, Mohammad
Tiberi, Gianluigi
author_facet Sani, Lorenzo
Vispa, Alessandro
Loretoni, Riccardo
Duranti, Michele
Ghavami, Navid
Alvarez Sánchez-Bayuela, Daniel
Caschera, Stefano
Paoli, Martina
Bigotti, Alessandra
Badia, Mario
Scorsipa, Michele
Raspa, Giovanni
Ghavami, Mohammad
Tiberi, Gianluigi
author_sort Sani, Lorenzo
collection PubMed
description MammoWave is a microwave imaging device for breast lesions detection, which operates using two (azimuthally rotating) antennas without any matching liquid. Images, subsequently obtained by resorting to Huygens Principle, are intensity maps, representing the homogeneity of tissues’ dielectric properties. In this paper, we propose to generate, for each breast, a set of conductivity weighted microwave images by using different values of conductivity in the Huygens Principle imaging algorithm. Next, microwave images’ parameters, i.e. features, are introduced to quantify the non-homogenous behaviour of the image. We empirically verify on 103 breasts that a selection of these features may allow distinction between breasts with no radiological finding (NF) and breasts with radiological findings (WF), i.e. with lesions which may be benign or malignant. Statistical significance was set at p<0.05. We obtained single features Area Under the receiver operating characteristic Curves (AUCs) spanning from 0.65 to 0.69. In addition, an empirical rule-of-thumb allowing breast assessment is introduced using a binary score S operating on an appropriate combination of features. Performances of such rule-of-thumb are evaluated empirically, obtaining a sensitivity of 74%, which increases to 82% when considering dense breasts only.
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spelling pubmed-80434132021-04-21 Breast lesion detection through MammoWave device: Empirical detection capability assessment of microwave images’ parameters Sani, Lorenzo Vispa, Alessandro Loretoni, Riccardo Duranti, Michele Ghavami, Navid Alvarez Sánchez-Bayuela, Daniel Caschera, Stefano Paoli, Martina Bigotti, Alessandra Badia, Mario Scorsipa, Michele Raspa, Giovanni Ghavami, Mohammad Tiberi, Gianluigi PLoS One Research Article MammoWave is a microwave imaging device for breast lesions detection, which operates using two (azimuthally rotating) antennas without any matching liquid. Images, subsequently obtained by resorting to Huygens Principle, are intensity maps, representing the homogeneity of tissues’ dielectric properties. In this paper, we propose to generate, for each breast, a set of conductivity weighted microwave images by using different values of conductivity in the Huygens Principle imaging algorithm. Next, microwave images’ parameters, i.e. features, are introduced to quantify the non-homogenous behaviour of the image. We empirically verify on 103 breasts that a selection of these features may allow distinction between breasts with no radiological finding (NF) and breasts with radiological findings (WF), i.e. with lesions which may be benign or malignant. Statistical significance was set at p<0.05. We obtained single features Area Under the receiver operating characteristic Curves (AUCs) spanning from 0.65 to 0.69. In addition, an empirical rule-of-thumb allowing breast assessment is introduced using a binary score S operating on an appropriate combination of features. Performances of such rule-of-thumb are evaluated empirically, obtaining a sensitivity of 74%, which increases to 82% when considering dense breasts only. Public Library of Science 2021-04-13 /pmc/articles/PMC8043413/ /pubmed/33848318 http://dx.doi.org/10.1371/journal.pone.0250005 Text en © 2021 Sani et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sani, Lorenzo
Vispa, Alessandro
Loretoni, Riccardo
Duranti, Michele
Ghavami, Navid
Alvarez Sánchez-Bayuela, Daniel
Caschera, Stefano
Paoli, Martina
Bigotti, Alessandra
Badia, Mario
Scorsipa, Michele
Raspa, Giovanni
Ghavami, Mohammad
Tiberi, Gianluigi
Breast lesion detection through MammoWave device: Empirical detection capability assessment of microwave images’ parameters
title Breast lesion detection through MammoWave device: Empirical detection capability assessment of microwave images’ parameters
title_full Breast lesion detection through MammoWave device: Empirical detection capability assessment of microwave images’ parameters
title_fullStr Breast lesion detection through MammoWave device: Empirical detection capability assessment of microwave images’ parameters
title_full_unstemmed Breast lesion detection through MammoWave device: Empirical detection capability assessment of microwave images’ parameters
title_short Breast lesion detection through MammoWave device: Empirical detection capability assessment of microwave images’ parameters
title_sort breast lesion detection through mammowave device: empirical detection capability assessment of microwave images’ parameters
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043413/
https://www.ncbi.nlm.nih.gov/pubmed/33848318
http://dx.doi.org/10.1371/journal.pone.0250005
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