Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape

An ideal anti-SARS-CoV-2 antibody would resist viral escape(1–3), have activity against diverse SARS-related coronaviruses(4–7), and be highly protective through viral neutralization(8–11) and effector functions(12,13). Understanding how these properties relate to each other and vary across epitopes...

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Autores principales: Starr, Tyler N., Czudnochowski, Nadine, Zatta, Fabrizia, Park, Young-Jun, Liu, Zhuoming, Addetia, Amin, Pinto, Dora, Beltramello, Martina, Hernandez, Patrick, Greaney, Allison J., Marzi, Roberta, Glass, William G., Zhang, Ivy, Dingens, Adam S., Bowen, John E., Wojcechowskyj, Jason A., De Marco, Anna, Rosen, Laura E., Zhou, Jiayi, Montiel-Ruiz, Martin, Kaiser, Hannah, Tucker, Heather, Housley, Michael P., di Iulio, Julia, Lombardo, Gloria, Agostini, Maria, Sprugasci, Nicole, Culap, Katja, Jaconi, Stefano, Meury, Marcel, Dellota, Exequiel, Cameroni, Elisabetta, Croll, Tristan I., Nix, Jay C., Havenar-Daughton, Colin, Telenti, Amalio, Lempp, Florian A., Pizzuto, Matteo S., Chodera, John D., Hebner, Christy M., Whelan, Sean P.J., Virgin, Herbert W., Veesler, David, Corti, Davide, Bloom, Jesse D., Snell, Gyorgy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043444/
https://www.ncbi.nlm.nih.gov/pubmed/33851154
http://dx.doi.org/10.1101/2021.04.06.438709

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