Cargando…

A trimeric hydrophobic zipper mediates the intramembrane assembly of SARS-CoV-2 spike

The S protein of the SARS-CoV-2 is a Type I membrane protein that mediates membrane fusion and viral entry. A vast amount of structural information is available for the ectodomain of S, a primary target by the host immune system, but much less is known regarding its transmembrane domain (TMD) and it...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Qingshan, Chou, James J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043453/ https://www.ncbi.nlm.nih.gov/pubmed/33851163 http://dx.doi.org/10.1101/2021.04.09.439203

Ejemplares similares

Stabilizing the closed SARS-CoV-2 spike trimer
por: Juraszek, Jarek, et al.
Publicado: (2021)

Intricacies of the SARS-CoV-2 spike transmembrane trimer organization
por: Aliper, Elena T., et al.
Publicado: (2022)

Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein
por: Zhang, Si Min, et al.
Publicado: (2018)

Computational and comparative investigation of hydrophobic profile of spike protein of SARS-CoV-2 and SARS-CoV
por: Shekhawat, Uma, et al.
Publicado: (2022)

An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer
por: Suryadevara, Naveenchandra, et al.
Publicado: (2022)

A Uniquely Stable Trimeric Model of SARS-CoV-2 Spike Transmembrane Domain
por: Aliper, Elena T., et al.
Publicado: (2022)

Optimizing high-yield production of SARS-CoV-2 soluble spike trimers for serology assays
por: Esposito, Dominic, et al.
Publicado: (2020)

Optimizing high-yield production of SARS-CoV-2 soluble spike trimers for serology assays
por: Esposito, Dominic, et al.
Publicado: (2020)

Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein
por: Vankadari, Naveen
Publicado: (2020)

The SARS-CoV-2 spike protein reversibly samples an open-trimer conformation exposing novel epitopes
por: Shoemaker, Sophie R., et al.
Publicado: (2022)

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
por: Hanke, Leo, et al.
Publicado: (2022)

Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum
por: dos-Santos, Júlio Souza, et al.
Publicado: (2022)

Structural insights into the Omicron spike trimer: tackling the challenges of continuously evolving SARS-CoV-2 variants
por: Ou, Junxian, et al.
Publicado: (2022)

A Platform Incorporating Trimeric Antigens into Self-Assembling Nanoparticles Reveals SARS-CoV-2-Spike Nanoparticles to Elicit Substantially Higher Neutralizing Responses than Spike Alone
por: Zhang, Baoshan, et al.
Publicado: (2020)

A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone
por: Zhang, Baoshan, et al.
Publicado: (2020)

A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2
por: Gupta, Ankit, et al.
Publicado: (2021)

D614G substitution at the hinge region enhances the stability of trimeric SARS-CoV-2 spike protein
por: Yazhini, Arangasamy, et al.
Publicado: (2021)

Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer
por: Guerrini, Giuditta, et al.
Publicado: (2023)

Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype
por: Kugathasan, Ruthiran, et al.
Publicado: (2023)

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM
por: Xu, Cong, et al.
Publicado: (2021)

Predicted pH-dependent stability of SARS-CoV-2 spike protein trimer from interfacial acidic groups
por: Lobo, Vanessa R., et al.
Publicado: (2021)

Inhibition of SARS-CoV-2 infection in cellular systems using engineered trimeric receptor-binding domain of spike protein
por: Liu, Angela Rose, et al.
Publicado: (2023)

Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
por: Azad, Taha, et al.
Publicado: (2020)

Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant
por: Akache, Bassel, et al.
Publicado: (2021)

SARS‐CoV‐2 spike trimer vaccine expressed in Nicotiana benthamiana adjuvanted with Alum elicits protective immune responses in mice
por: Song, Shi‐Jian, et al.
Publicado: (2022)

A trimeric spike-based COVID-19 vaccine candidate induces broad neutralization against SARS-CoV-2 variants
por: Gao, Feixia, et al.
Publicado: (2023)

Identification of Potential Lead Compounds Targeting Novel Druggable Cavity of SARS-CoV-2 Spike Trimer by Molecular Dynamics Simulations
por: Zhao, Yizhen, et al.
Publicado: (2023)

Well-Defined Heparin Mimetics Can Inhibit Binding of the Trimeric Spike of SARS-CoV-2 in a Length-Dependent Manner
por: Sun, Lifeng, et al.
Publicado: (2023)

C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein
por: Gargantilla, Marta, et al.
Publicado: (2023)

IgG1-Dominant Antibody Response Induced by Recombinant Trimeric SARS-CoV-2 Spike Protein with PIKA Adjuvant
por: Wang, Jingxia, et al.
Publicado: (2023)

Structural dynamic changes in the SARS-CoV and SARS-CoV-2 S spike assemblies upon ACE2 activation
por: Chen, Chengbo, et al.
Publicado: (2022)

Extensive flavivirus E trimer breathing accompanies stem zippering of the post‐fusion hairpin
por: Medits, Iris, et al.
Publicado: (2020)

Rhomboid-catalyzed intramembrane proteolysis requires hydrophobic matching with the surrounding lipid bilayer
por: Engberg, Oskar, et al.
Publicado: (2022)

Antibody-mediated immunity to SARS-CoV-2 spike
por: Errico, John M., et al.
Publicado: (2022)

SARS-CoV heptad repeat 2 is a trimer of parallel helices
por: Celigoy, Jessica, et al.
Publicado: (2011)

Oligomerization of the SARS-CoV S glycoprotein: dimerization of the N-terminus and trimerization of the ectodomain
por: Xiao, Xiaodong, et al.
Publicado: (2004)

Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations
por: Sakkiah, Sugunadevi, et al.
Publicado: (2021)

High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens
por: Counoupas, Claudio, et al.
Publicado: (2022)

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer
por: Zhan, Wuqiang, et al.
Publicado: (2022)

Intranasal immunization with recombinant Vaccinia virus encoding trimeric SARS-CoV-2 spike receptor-binding domain induces neutralizing antibody
por: Cao, Xiaoling, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lj0vbg071ujqp529u7fr4n37kj