Cargando…

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2

Despite the great promise of vaccines, the COVID-19 pandemic is ongoing and future serious outbreaks are highly likely, so that multi-pronged containment strategies will be required for many years. Nanobodies are the smallest naturally occurring single domain antigen binding proteins identified to d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mast, Fred D., Fridy, Peter C., Ketaren, Natalia E., Wang, Junjie, Jacobs, Erica Y., Olivier, Jean Paul, Sanyal, Tanmoy, Molloy, Kelly R., Schmidt, Fabian, Rutkowska, Magda, Weisblum, Yiska, Rich, Lucille M., Vanderwall, Elizabeth R., Dambrauskas, Nicolas, Vigdorovich, Vladimir, Keegan, Sarah, Jiler, Jacob B., Stein, Milana E., Olinares, Paul Dominic B., Hatziioannou, Theodora, Sather, D. Noah, Debley, Jason S., Fenyö, David, Sali, Andrej, Bieniasz, Paul D., Aitchison, John D., Chait, Brian T., Rout, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043454/ https://www.ncbi.nlm.nih.gov/pubmed/33851164 http://dx.doi.org/10.1101/2021.04.08.438911

Ejemplares similares

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape
por: Mast, Fred D, et al.
Publicado: (2021)

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus
por: Ketaren, Natalia E., et al.
Publicado: (2023)

Abstract 2702: Highly synergistic combinations of nanobodies that target SARS-CoV-2 reduce viral load in hACE2 transgenic mice
por: Olivier, Paul, et al.
Publicado: (2023)

Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection
por: Poston, Daniel, et al.
Publicado: (2020)

Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection
por: Poston, Daniel, et al.
Publicado: (2020)

VPS29 Exerts Opposing Effects on Endocytic Viral Entry
por: Poston, Daniel, et al.
Publicado: (2022)

Expanding and improving nanobody repertoires using a yeast display method: Targeting SARS-CoV-2
por: Cross, Frederick R., et al.
Publicado: (2023)

Plasma Neutralization of the SARS-CoV-2 Omicron Variant
por: Schmidt, Fabian, et al.
Publicado: (2021)

Plasma neutralization properties of the SARS-CoV-2 Omicron variant
por: Schmidt, Fabian, et al.
Publicado: (2021)

Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection
por: Gaebler, Christian, et al.
Publicado: (2022)

Temperature synchronisation of circadian rhythms in primary human airway epithelial cells from children
por: Powell, Weston T, et al.
Publicado: (2022)

Repertoire comparison of the B-cell receptor-encoding loci in humans and rhesus macaques by next-generation sequencing
por: Vigdorovich, Vladimir, et al.
Publicado: (2016)

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses
por: Schmidt, Fabian, et al.
Publicado: (2020)

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses
por: Schmidt, Fabian, et al.
Publicado: (2020)

Persistent Nonviral Plasmid Vector in Nasal Tissues Causes False-Positive SARS-CoV-2 Diagnostic Nucleic Acid Tests
por: Beck, Ingrid A., et al.
Publicado: (2022)

Vaccination with SARS-CoV-2 variants of concern protects mice from challenge with wild-type virus
por: Amanat, Fatima, et al.
Publicado: (2021)

GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome
por: Sekedat, Matthew D, et al.
Publicado: (2010)

Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID19 Patients
por: Luchsinger, Larry L., et al.
Publicado: (2020)

Plasma From Recovered COVID-19 Patients Inhibits Spike Protein Binding to ACE2 in a Microsphere-Based Inhibition Assay
por: Gniffke, Edward P, et al.
Publicado: (2020)

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
por: Weisblum, Yiska, et al.
Publicado: (2020)

Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID-19 Patients
por: Luchsinger, Larry L., et al.
Publicado: (2020)

Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies
por: Greaney, Allison J., et al.
Publicado: (2021)

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies
por: Greaney, Allison J., et al.
Publicado: (2021)

Inactivation of Material from SARS-CoV-2-Infected Primary Airway Epithelial Cell Cultures
por: Barrow, Kaitlyn A., et al.
Publicado: (2021)

Assisted Evolution Enables HIV-1 to Overcome a High TRIM5α-Imposed Genetic Barrier to Rhesus Macaque Tropism
por: Soll, Steven J., et al.
Publicado: (2013)

Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells
por: Okoloko, Oghenemega, et al.
Publicado: (2021)

SIV Nef Proteins Recruit the AP-2 Complex to Antagonize Tetherin and Facilitate Virion Release
por: Zhang, Fengwen, et al.
Publicado: (2011)

The MIDAS domain of AAA mechanoenzyme Mdn1 forms catch bonds with two different substrates
por: Mickolajczyk, Keith J, et al.
Publicado: (2022)

Structural basis of substrate recognition by a polypeptide processing and secretion transporter
por: Kieuvongngam, Virapat, et al.
Publicado: (2020)

Germinal center activity and B cell maturation are associated with protective antibody responses against Plasmodium pre-erythrocytic infection
por: Visweswaran, Ganesh Ram R., et al.
Publicado: (2022)

Coimmunization with Preerythrocytic Antigens alongside Circumsporozoite Protein Can Enhance Sterile Protection against Plasmodium Sporozoite Infection
por: Vigdorovich, Vladimir, et al.
Publicado: (2023)

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies
por: Muecksch, Frauke, et al.
Publicado: (2021)

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
por: Muecksch, Frauke, et al.
Publicado: (2021)

A nucleotide binding–independent role for γ-tubulin in microtubule capping and cell division
por: Berman, Adi Y., et al.
Publicado: (2023)

Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
por: Mast, Fred D., et al.
Publicado: (2020)

Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replication
por: Vanderwall, Elizabeth R., et al.
Publicado: (2022)

The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators
por: Orlova, Natalia, et al.
Publicado: (2017)

Analysis of the mechanosensor channel functionality of TACAN
por: Niu, Yiming, et al.
Publicado: (2021)

A robust pipeline for rapid production of versatile nanobody repertoires
por: Fridy, Peter C., et al.
Publicado: (2014)

APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
por: Bohn, Jennifer A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_14bli46sfd3cudbcpi5hhvtokk