Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2

BACKGROUND: Individuals with chronic inflammatory diseases (CID) are frequently treated with immunosuppressive medications that can increase their risk of severe COVID-19. While novel mRNA-based SARS-CoV-2 vaccination platforms provide robust protection in immunocompetent individuals, the immunogeni...

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Detalles Bibliográficos
Autores principales: Deepak, Parakkal, Kim, Wooseob, Paley, Michael A., Yang, Monica, Carvidi, Alexander B., El-Qunni, Alia A., Haile, Alem, Huang, Katherine, Kinnett, Baylee, Liebeskind, Mariel J., Liu, Zhuoming, McMorrow, Lily E., Paez, Diana, Perantie, Dana C., Schriefer, Rebecca E., Sides, Shannon E., Thapa, Mahima, Gergely, Maté, Abushamma, Suha, Klebert, Michael, Mitchell, Lynne, Nix, Darren, Graf, Jonathan, Taylor, Kimberly E., Chahin, Salim, Ciorba, Matthew A., Katz, Patricia, Matloubian, Mehrdad, O’Halloran, Jane A., Presti, Rachel M., Wu, Gregory F., Whelan, Sean P.J., Buchser, William J., Gensler, Lianne S., Nakamura, Mary C., Ellebedy, Ali H., Kim, Alfred H.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043473/
https://www.ncbi.nlm.nih.gov/pubmed/33851176
http://dx.doi.org/10.1101/2021.04.05.21254656

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