Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum

We tested human sera from large, demographically balanced cohorts of BNT162b2 vaccine recipients (n=51) and COVID-19 patients (n=44) for neutralizing antibodies against SARS-CoV-2 variants B.1.1.7 and B.1.351. Although the effect is more pronounced in the vaccine cohort, both B.1.1.7 and B.1.351 sho...

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Autores principales: Bates, Timothy A., Leier, Hans C., Lyski, Zoe L., McBride, Savannah K., Coulter, Felicity J., Weinstein, Jules B., Goodman, James R., Lu, Zhengchun, Siegel, Sarah A. R., Sullivan, Peter, Strnad, Matt, Brunton, Amanda E., Lee, David X., Curlin, Marcel E., Messer, William B., Tafesse, Fikadu G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043482/
https://www.ncbi.nlm.nih.gov/pubmed/33851185
http://dx.doi.org/10.1101/2021.04.04.21254881
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author Bates, Timothy A.
Leier, Hans C.
Lyski, Zoe L.
McBride, Savannah K.
Coulter, Felicity J.
Weinstein, Jules B.
Goodman, James R.
Lu, Zhengchun
Siegel, Sarah A. R.
Sullivan, Peter
Strnad, Matt
Brunton, Amanda E.
Lee, David X.
Curlin, Marcel E.
Messer, William B.
Tafesse, Fikadu G.
author_facet Bates, Timothy A.
Leier, Hans C.
Lyski, Zoe L.
McBride, Savannah K.
Coulter, Felicity J.
Weinstein, Jules B.
Goodman, James R.
Lu, Zhengchun
Siegel, Sarah A. R.
Sullivan, Peter
Strnad, Matt
Brunton, Amanda E.
Lee, David X.
Curlin, Marcel E.
Messer, William B.
Tafesse, Fikadu G.
author_sort Bates, Timothy A.
collection PubMed
description We tested human sera from large, demographically balanced cohorts of BNT162b2 vaccine recipients (n=51) and COVID-19 patients (n=44) for neutralizing antibodies against SARS-CoV-2 variants B.1.1.7 and B.1.351. Although the effect is more pronounced in the vaccine cohort, both B.1.1.7 and B.1.351 show significantly reduced levels of neutralization by vaccinated and convalescent sera. Age is negatively correlated with neutralization in vaccinee, and levels of variant-specific RBD antibodies are proportional to neutralizing activities.
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spelling pubmed-80434822021-04-14 Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum Bates, Timothy A. Leier, Hans C. Lyski, Zoe L. McBride, Savannah K. Coulter, Felicity J. Weinstein, Jules B. Goodman, James R. Lu, Zhengchun Siegel, Sarah A. R. Sullivan, Peter Strnad, Matt Brunton, Amanda E. Lee, David X. Curlin, Marcel E. Messer, William B. Tafesse, Fikadu G. medRxiv Article We tested human sera from large, demographically balanced cohorts of BNT162b2 vaccine recipients (n=51) and COVID-19 patients (n=44) for neutralizing antibodies against SARS-CoV-2 variants B.1.1.7 and B.1.351. Although the effect is more pronounced in the vaccine cohort, both B.1.1.7 and B.1.351 show significantly reduced levels of neutralization by vaccinated and convalescent sera. Age is negatively correlated with neutralization in vaccinee, and levels of variant-specific RBD antibodies are proportional to neutralizing activities. Cold Spring Harbor Laboratory 2021-04-09 /pmc/articles/PMC8043482/ /pubmed/33851185 http://dx.doi.org/10.1101/2021.04.04.21254881 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Bates, Timothy A.
Leier, Hans C.
Lyski, Zoe L.
McBride, Savannah K.
Coulter, Felicity J.
Weinstein, Jules B.
Goodman, James R.
Lu, Zhengchun
Siegel, Sarah A. R.
Sullivan, Peter
Strnad, Matt
Brunton, Amanda E.
Lee, David X.
Curlin, Marcel E.
Messer, William B.
Tafesse, Fikadu G.
Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum
title Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum
title_full Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum
title_fullStr Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum
title_full_unstemmed Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum
title_short Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum
title_sort neutralization of sars-cov-2 variants by convalescent and vaccinated serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043482/
https://www.ncbi.nlm.nih.gov/pubmed/33851185
http://dx.doi.org/10.1101/2021.04.04.21254881
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