Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 infection. We profiled MIS-C, adult COVID-19, and healthy pediatric and adult individuals using single-cell RNA sequencing, flo...

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Autores principales: Ramaswamy, Anjali, Brodsky, Nina N., Sumida, Tomokazu S., Comi, Michela, Asashima, Hiromitsu, Hoehn, Kenneth B., Li, Ningshan, Liu, Yunqing, Shah, Aagam, Ravindra, Neal G., Bishai, Jason, Khan, Alamzeb, Lau, William, Sellers, Brian, Bansal, Neha, Guerrerio, Pamela, Unterman, Avraham, Habet, Victoria, Rice, Andrew J., Catanzaro, Jason, Chandnani, Harsha, Lopez, Merrick, Kaminski, Naftali, Dela Cruz, Charles S., Tsang, John S., Wang, Zuoheng, Yan, Xiting, Kleinstein, Steven H., van Dijk, David, Pierce, Richard W., Hafler, David A., Lucas, Carrie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043654/
https://www.ncbi.nlm.nih.gov/pubmed/33891889
http://dx.doi.org/10.1016/j.immuni.2021.04.003

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