Cargando…

Pattern of survival of breast cancer patients in a tertiary hospital in South West Nigeria

BACKGROUND OF THE STUDY: Breast cancer is the most common cancer among women in both developed and developing nations. The survival of breast cancer is increasing in developed countries with improved treatment modalities, while still very poor in developing countries. In Nigeria, few breast cancer s...

Descripción completa

Detalles Bibliográficos
Autores principales: Ali-Gombe, Musa, Mustapha, Muhammad Inuwa, Folasire, Ayorinde, Ntekim, Atara, Campbell, Oladapo Babatunde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043689/
https://www.ncbi.nlm.nih.gov/pubmed/33889201
http://dx.doi.org/10.3332/ecancer.2021.1192
_version_ 1783678351355936768
author Ali-Gombe, Musa
Mustapha, Muhammad Inuwa
Folasire, Ayorinde
Ntekim, Atara
Campbell, Oladapo Babatunde
author_facet Ali-Gombe, Musa
Mustapha, Muhammad Inuwa
Folasire, Ayorinde
Ntekim, Atara
Campbell, Oladapo Babatunde
author_sort Ali-Gombe, Musa
collection PubMed
description BACKGROUND OF THE STUDY: Breast cancer is the most common cancer among women in both developed and developing nations. The survival of breast cancer is increasing in developed countries with improved treatment modalities, while still very poor in developing countries. In Nigeria, few breast cancer survival data are available. RESEARCH DESIGN: This is a retrospective cross-sectional study. OBJECTIVES: To determine the survival of breast cancer patients and possible factors influencing it. METHODOLOGY: Socio-demographic and clinical variables from treatment records and case notes of breast cancer patients treated from 1 January 2004 to 31 December 2008 at the Department of Radiation Oncology, University College Hospital, Ibadan. The status of patients was determined at 2 and 5 years after diagnosis. The survival of patients with breast cancer was compared using Log Rank test according to socio-demographic and clinical variables. The median survival times were obtained from the Kaplan–Meier survival curve. Cox’s proportional hazard model was fitted for those that were statistically significant in the Log Rank test. Missing data were reported as unknown, not documented or missing. RESULTS: A total of 378 patients were analysed. Age ranged between 22.0 and 87.0 years with mean of 47.6 (standard deviation (SD) = 11.2) years. Almost all patients were females (98.4%). More than half (55.3%) presented at stage III, 28.0% had metastasis and the stage was unknown in about 6.6% of the patients. Invasive ductal carcinoma was the most prevalent histology (89.2%). Only 124 (32.8%) patients had their histological grade stated and most of the patients had no immunohistochemistry done. All the patients had radiotherapy, chemotherapy and surgery. About 25.1% of the patients were lost to follow up. The 2- and 5-year survival rates were 56.4% and 37.6%, respectively. The 2- and 5-year survival rates according to stage were stage I (80.0% and 66.7%), stage II (67.7% and 57.6%), stage III (51.4% and 27.9%) and stage IV (37.9% and 13.8%). Median survival time was 41 months (95%CI = 35.0–44.0). The disease-free survival at 2 and 5 years was 66.6% and 60.3%, respectively. Median time for recurrence was 8.0 months. Level of education, height, tumour unilaterality, clinical tumour size, stage at presentation, presence of distant metastases, clinical axillary lymph node metastasis, supraclavicular node metastasis, mode of surgery and axillary clearance were found to have statistically significant association with survival. CONCLUSION: A large number of the patients in our study presented at a young age, late with advanced stage disease which results in poor survival outcome.
format Online
Article
Text
id pubmed-8043689
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cancer Intelligence
record_format MEDLINE/PubMed
spelling pubmed-80436892021-04-21 Pattern of survival of breast cancer patients in a tertiary hospital in South West Nigeria Ali-Gombe, Musa Mustapha, Muhammad Inuwa Folasire, Ayorinde Ntekim, Atara Campbell, Oladapo Babatunde Ecancermedicalscience Clinical Study BACKGROUND OF THE STUDY: Breast cancer is the most common cancer among women in both developed and developing nations. The survival of breast cancer is increasing in developed countries with improved treatment modalities, while still very poor in developing countries. In Nigeria, few breast cancer survival data are available. RESEARCH DESIGN: This is a retrospective cross-sectional study. OBJECTIVES: To determine the survival of breast cancer patients and possible factors influencing it. METHODOLOGY: Socio-demographic and clinical variables from treatment records and case notes of breast cancer patients treated from 1 January 2004 to 31 December 2008 at the Department of Radiation Oncology, University College Hospital, Ibadan. The status of patients was determined at 2 and 5 years after diagnosis. The survival of patients with breast cancer was compared using Log Rank test according to socio-demographic and clinical variables. The median survival times were obtained from the Kaplan–Meier survival curve. Cox’s proportional hazard model was fitted for those that were statistically significant in the Log Rank test. Missing data were reported as unknown, not documented or missing. RESULTS: A total of 378 patients were analysed. Age ranged between 22.0 and 87.0 years with mean of 47.6 (standard deviation (SD) = 11.2) years. Almost all patients were females (98.4%). More than half (55.3%) presented at stage III, 28.0% had metastasis and the stage was unknown in about 6.6% of the patients. Invasive ductal carcinoma was the most prevalent histology (89.2%). Only 124 (32.8%) patients had their histological grade stated and most of the patients had no immunohistochemistry done. All the patients had radiotherapy, chemotherapy and surgery. About 25.1% of the patients were lost to follow up. The 2- and 5-year survival rates were 56.4% and 37.6%, respectively. The 2- and 5-year survival rates according to stage were stage I (80.0% and 66.7%), stage II (67.7% and 57.6%), stage III (51.4% and 27.9%) and stage IV (37.9% and 13.8%). Median survival time was 41 months (95%CI = 35.0–44.0). The disease-free survival at 2 and 5 years was 66.6% and 60.3%, respectively. Median time for recurrence was 8.0 months. Level of education, height, tumour unilaterality, clinical tumour size, stage at presentation, presence of distant metastases, clinical axillary lymph node metastasis, supraclavicular node metastasis, mode of surgery and axillary clearance were found to have statistically significant association with survival. CONCLUSION: A large number of the patients in our study presented at a young age, late with advanced stage disease which results in poor survival outcome. Cancer Intelligence 2021-02-25 /pmc/articles/PMC8043689/ /pubmed/33889201 http://dx.doi.org/10.3332/ecancer.2021.1192 Text en © the authors; licensee ecancermedicalscience. https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Ali-Gombe, Musa
Mustapha, Muhammad Inuwa
Folasire, Ayorinde
Ntekim, Atara
Campbell, Oladapo Babatunde
Pattern of survival of breast cancer patients in a tertiary hospital in South West Nigeria
title Pattern of survival of breast cancer patients in a tertiary hospital in South West Nigeria
title_full Pattern of survival of breast cancer patients in a tertiary hospital in South West Nigeria
title_fullStr Pattern of survival of breast cancer patients in a tertiary hospital in South West Nigeria
title_full_unstemmed Pattern of survival of breast cancer patients in a tertiary hospital in South West Nigeria
title_short Pattern of survival of breast cancer patients in a tertiary hospital in South West Nigeria
title_sort pattern of survival of breast cancer patients in a tertiary hospital in south west nigeria
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043689/
https://www.ncbi.nlm.nih.gov/pubmed/33889201
http://dx.doi.org/10.3332/ecancer.2021.1192
work_keys_str_mv AT aligombemusa patternofsurvivalofbreastcancerpatientsinatertiaryhospitalinsouthwestnigeria
AT mustaphamuhammadinuwa patternofsurvivalofbreastcancerpatientsinatertiaryhospitalinsouthwestnigeria
AT folasireayorinde patternofsurvivalofbreastcancerpatientsinatertiaryhospitalinsouthwestnigeria
AT ntekimatara patternofsurvivalofbreastcancerpatientsinatertiaryhospitalinsouthwestnigeria
AT campbelloladapobabatunde patternofsurvivalofbreastcancerpatientsinatertiaryhospitalinsouthwestnigeria