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Prenatal metal mixtures and sex-specific infant negative affectivity

Prenatal exposure to metals has been associated with a range of adverse neurocognitive outcomes; however, associations with early behavioral development are less well understood. We examined joint exposure to multiple co-occurring metals in relation to infant negative affect, a stable temperamental...

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Autores principales: Cowell, Whitney, Colicino, Elena, Levin-Schwartz, Yuri, Enlow, Michelle Bosquet, Amarasiriwardena, Chitra, Andra, Syam S., Gennings, Chris, Wright, Robert O., Wright, Rosalind J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043734/
https://www.ncbi.nlm.nih.gov/pubmed/33870019
http://dx.doi.org/10.1097/EE9.0000000000000147
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author Cowell, Whitney
Colicino, Elena
Levin-Schwartz, Yuri
Enlow, Michelle Bosquet
Amarasiriwardena, Chitra
Andra, Syam S.
Gennings, Chris
Wright, Robert O.
Wright, Rosalind J.
author_facet Cowell, Whitney
Colicino, Elena
Levin-Schwartz, Yuri
Enlow, Michelle Bosquet
Amarasiriwardena, Chitra
Andra, Syam S.
Gennings, Chris
Wright, Robert O.
Wright, Rosalind J.
author_sort Cowell, Whitney
collection PubMed
description Prenatal exposure to metals has been associated with a range of adverse neurocognitive outcomes; however, associations with early behavioral development are less well understood. We examined joint exposure to multiple co-occurring metals in relation to infant negative affect, a stable temperamental trait linked to psychopathology among children and adults. METHODS: Analyses included 308 mother-infant pairs enrolled in the PRISM pregnancy cohort. We measured As, Ba, Cd, Cs, Cr, Pb, and Sb in urine, collected on average during late pregnancy, by ICP-MS. At age 6 months, we assessed negative affect using the Infant Behavior Questionnaire—Revised. We used Weighted Quantile Sum (WQS) regression with repeated holdout validation to estimate the joint association between the metals and global negative affectivity, as well as four subdomains (Fear, Sadness, Distress to Limitations, and Falling Reactivity). We also tested for a sex interaction with estimated stratified weights. RESULTS: In adjusted models, urinary metals were associated with higher scores on the Fear scale (β(WQS) = 0.20, 95% confidence interval [CI]: 0.09, 0.30), which captures behavioral inhibition, characterized by startle or distress to sudden changes in the environment and inhibited approach to novelty. We observed a significant sex interaction (95% CI for the cross-product term: −0.19, −0.01), and stratified weights showed girls (61.6%) contributed substantially more to the mixture effect compared with boys (38.4%). Overall, Ba contributed the greatest mixture weight (22.5%), followed by Cs (14.9%) and As (14.6%). CONCLUSIONS: Prenatal exposure to metals was associated with increased infant scores on the temperamental domain of fear, with girls showing particular sensitivity. Key words: Prenatal; Metals; Mixtures; Temperament; Infancy; Negative affect
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spelling pubmed-80437342021-04-16 Prenatal metal mixtures and sex-specific infant negative affectivity Cowell, Whitney Colicino, Elena Levin-Schwartz, Yuri Enlow, Michelle Bosquet Amarasiriwardena, Chitra Andra, Syam S. Gennings, Chris Wright, Robert O. Wright, Rosalind J. Environ Epidemiol Original Research Article Prenatal exposure to metals has been associated with a range of adverse neurocognitive outcomes; however, associations with early behavioral development are less well understood. We examined joint exposure to multiple co-occurring metals in relation to infant negative affect, a stable temperamental trait linked to psychopathology among children and adults. METHODS: Analyses included 308 mother-infant pairs enrolled in the PRISM pregnancy cohort. We measured As, Ba, Cd, Cs, Cr, Pb, and Sb in urine, collected on average during late pregnancy, by ICP-MS. At age 6 months, we assessed negative affect using the Infant Behavior Questionnaire—Revised. We used Weighted Quantile Sum (WQS) regression with repeated holdout validation to estimate the joint association between the metals and global negative affectivity, as well as four subdomains (Fear, Sadness, Distress to Limitations, and Falling Reactivity). We also tested for a sex interaction with estimated stratified weights. RESULTS: In adjusted models, urinary metals were associated with higher scores on the Fear scale (β(WQS) = 0.20, 95% confidence interval [CI]: 0.09, 0.30), which captures behavioral inhibition, characterized by startle or distress to sudden changes in the environment and inhibited approach to novelty. We observed a significant sex interaction (95% CI for the cross-product term: −0.19, −0.01), and stratified weights showed girls (61.6%) contributed substantially more to the mixture effect compared with boys (38.4%). Overall, Ba contributed the greatest mixture weight (22.5%), followed by Cs (14.9%) and As (14.6%). CONCLUSIONS: Prenatal exposure to metals was associated with increased infant scores on the temperamental domain of fear, with girls showing particular sensitivity. Key words: Prenatal; Metals; Mixtures; Temperament; Infancy; Negative affect Lippincott Williams & Wilkins 2021-04-02 /pmc/articles/PMC8043734/ /pubmed/33870019 http://dx.doi.org/10.1097/EE9.0000000000000147 Text en Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Cowell, Whitney
Colicino, Elena
Levin-Schwartz, Yuri
Enlow, Michelle Bosquet
Amarasiriwardena, Chitra
Andra, Syam S.
Gennings, Chris
Wright, Robert O.
Wright, Rosalind J.
Prenatal metal mixtures and sex-specific infant negative affectivity
title Prenatal metal mixtures and sex-specific infant negative affectivity
title_full Prenatal metal mixtures and sex-specific infant negative affectivity
title_fullStr Prenatal metal mixtures and sex-specific infant negative affectivity
title_full_unstemmed Prenatal metal mixtures and sex-specific infant negative affectivity
title_short Prenatal metal mixtures and sex-specific infant negative affectivity
title_sort prenatal metal mixtures and sex-specific infant negative affectivity
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043734/
https://www.ncbi.nlm.nih.gov/pubmed/33870019
http://dx.doi.org/10.1097/EE9.0000000000000147
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