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Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia

PURPOSE: Influenza virus infections are a key cause of community-acquired pneumonia (CAP). Cardiovascular events (CVEs) are common among CAP and influenza patients, but there have been few population-based studies of influenza-related pneumonia (Flu-p) patients published to date. METHODS: A retrospe...

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Autores principales: Chen, Liang, Han, Xiudi, Li, YanLi, Zhang, Chunxiao, Xing, Xiqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043795/
https://www.ncbi.nlm.nih.gov/pubmed/33859482
http://dx.doi.org/10.2147/IDR.S305509
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author Chen, Liang
Han, Xiudi
Li, YanLi
Zhang, Chunxiao
Xing, Xiqian
author_facet Chen, Liang
Han, Xiudi
Li, YanLi
Zhang, Chunxiao
Xing, Xiqian
author_sort Chen, Liang
collection PubMed
description PURPOSE: Influenza virus infections are a key cause of community-acquired pneumonia (CAP). Cardiovascular events (CVEs) are common among CAP and influenza patients, but there have been few population-based studies of influenza-related pneumonia (Flu-p) patients published to date. METHODS: A retrospective analysis of 1191 immunocompetent hospitalized adult Flu-p patients from January 2012 to December 2018 in five teaching hospitals in China was conducted. RESULTS: A total of 24.6% (293/1191) of patients developed at least one form of CVE-related complication while hospitalized. In a multivariate logistic regression analysis, hypertension, cerebrovascular disease, coronary artery disease, preexisting heart failure, systolic blood pressure <90 mmHg, respiratory rates ≥30 breaths/min, a lymphocyte count <0.8×10(9)/L, PaO(2)/FiO(2) <300 mmHg, and systemic corticosteroid administration were independently associated with the incidence of CVEs; while early neuraminidase inhibitor treatment and angiotensin converting enzyme inhibitors/angiotensin II receptor blocker treatment were associated with a lower risk of CVEs. After controlling for potential confounding variables, we determined that CVEs were linked to a higher risk of 30-day mortality (OR 3.307, 95% CI 2.198–4.975, p < 0.001) in Flu-p patients. CONCLUSION: CVE-related complications are common among hospitalized Flu-p patients and are associated with negative patient outcomes. Clarifying these CVE-related risk factors can aid in their clinical prevention and management.
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spelling pubmed-80437952021-04-14 Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia Chen, Liang Han, Xiudi Li, YanLi Zhang, Chunxiao Xing, Xiqian Infect Drug Resist Original Research PURPOSE: Influenza virus infections are a key cause of community-acquired pneumonia (CAP). Cardiovascular events (CVEs) are common among CAP and influenza patients, but there have been few population-based studies of influenza-related pneumonia (Flu-p) patients published to date. METHODS: A retrospective analysis of 1191 immunocompetent hospitalized adult Flu-p patients from January 2012 to December 2018 in five teaching hospitals in China was conducted. RESULTS: A total of 24.6% (293/1191) of patients developed at least one form of CVE-related complication while hospitalized. In a multivariate logistic regression analysis, hypertension, cerebrovascular disease, coronary artery disease, preexisting heart failure, systolic blood pressure <90 mmHg, respiratory rates ≥30 breaths/min, a lymphocyte count <0.8×10(9)/L, PaO(2)/FiO(2) <300 mmHg, and systemic corticosteroid administration were independently associated with the incidence of CVEs; while early neuraminidase inhibitor treatment and angiotensin converting enzyme inhibitors/angiotensin II receptor blocker treatment were associated with a lower risk of CVEs. After controlling for potential confounding variables, we determined that CVEs were linked to a higher risk of 30-day mortality (OR 3.307, 95% CI 2.198–4.975, p < 0.001) in Flu-p patients. CONCLUSION: CVE-related complications are common among hospitalized Flu-p patients and are associated with negative patient outcomes. Clarifying these CVE-related risk factors can aid in their clinical prevention and management. Dove 2021-04-09 /pmc/articles/PMC8043795/ /pubmed/33859482 http://dx.doi.org/10.2147/IDR.S305509 Text en © 2021 Chen et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Chen, Liang
Han, Xiudi
Li, YanLi
Zhang, Chunxiao
Xing, Xiqian
Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia
title Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia
title_full Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia
title_fullStr Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia
title_full_unstemmed Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia
title_short Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia
title_sort complications of cardiovascular events in patients hospitalized with influenza-related pneumonia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043795/
https://www.ncbi.nlm.nih.gov/pubmed/33859482
http://dx.doi.org/10.2147/IDR.S305509
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