Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles

PURPOSE: Nanocarriers, with a high drug loading content and good safety, to achieve desirable therapeutic effect are always the goals for industry and research. METHODS AND RESULTS: In the present study, we developed a docetaxel loaded poly-2-oxazoline polymer micellar system which employed poly-2-b...

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Autores principales: Xu, Min, Yao, Chong, Zhang, Wei, Gao, Shen, Zou, Hao, Gao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043799/
https://www.ncbi.nlm.nih.gov/pubmed/33859475
http://dx.doi.org/10.2147/IJN.S298093
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author Xu, Min
Yao, Chong
Zhang, Wei
Gao, Shen
Zou, Hao
Gao, Jing
author_facet Xu, Min
Yao, Chong
Zhang, Wei
Gao, Shen
Zou, Hao
Gao, Jing
author_sort Xu, Min
collection PubMed
description PURPOSE: Nanocarriers, with a high drug loading content and good safety, to achieve desirable therapeutic effect are always the goals for industry and research. METHODS AND RESULTS: In the present study, we developed a docetaxel loaded poly-2-oxazoline polymer micellar system which employed poly-2-butyl-2 oxazoline and poly-2-methyl-2 oxazoline as the hydrophobic chain and hydrophilic chain, respectively. This micellar system achieves a high load up to 25% against the docetaxel, and further demonstrates an IC50 as low as 40% of the commercialized docetaxel injection in vitro and a double maximum tolerated dose in MCF-7 cells in vivo. CONCLUSION: The high drug loading content, superior safety, and considerable anti-cancer activity make this newly developed docetaxel loaded poly(2-oxazoline) micelle go further in future clinical research.
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spelling pubmed-80437992021-04-14 Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles Xu, Min Yao, Chong Zhang, Wei Gao, Shen Zou, Hao Gao, Jing Int J Nanomedicine Original Research PURPOSE: Nanocarriers, with a high drug loading content and good safety, to achieve desirable therapeutic effect are always the goals for industry and research. METHODS AND RESULTS: In the present study, we developed a docetaxel loaded poly-2-oxazoline polymer micellar system which employed poly-2-butyl-2 oxazoline and poly-2-methyl-2 oxazoline as the hydrophobic chain and hydrophilic chain, respectively. This micellar system achieves a high load up to 25% against the docetaxel, and further demonstrates an IC50 as low as 40% of the commercialized docetaxel injection in vitro and a double maximum tolerated dose in MCF-7 cells in vivo. CONCLUSION: The high drug loading content, superior safety, and considerable anti-cancer activity make this newly developed docetaxel loaded poly(2-oxazoline) micelle go further in future clinical research. Dove 2021-04-09 /pmc/articles/PMC8043799/ /pubmed/33859475 http://dx.doi.org/10.2147/IJN.S298093 Text en © 2021 Xu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Xu, Min
Yao, Chong
Zhang, Wei
Gao, Shen
Zou, Hao
Gao, Jing
Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_full Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_fullStr Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_full_unstemmed Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_short Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_sort anti-cancer activity based on the high docetaxel loaded poly(2-oxazoline)s micelles
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043799/
https://www.ncbi.nlm.nih.gov/pubmed/33859475
http://dx.doi.org/10.2147/IJN.S298093
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