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Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention
The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the relevance of clinical evidence. In fact, several studies have documented the benefits of exercise training in the prevention of the cardiovascular risk. Abnormalities of insulin signaling transduction...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043859/ https://www.ncbi.nlm.nih.gov/pubmed/32737757 http://dx.doi.org/10.1007/s12265-020-10057-w |
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author | Iaccarino, Guido Franco, Danilo Sorriento, Daniela Strisciuglio, Teresa Barbato, Emanuele Morisco, Carmine |
author_facet | Iaccarino, Guido Franco, Danilo Sorriento, Daniela Strisciuglio, Teresa Barbato, Emanuele Morisco, Carmine |
author_sort | Iaccarino, Guido |
collection | PubMed |
description | The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the relevance of clinical evidence. In fact, several studies have documented the benefits of exercise training in the prevention of the cardiovascular risk. Abnormalities of insulin signaling transduction account for the impairment of insulin sensitivity and development of insulin resistance, which, in turn, is responsible for the enhancement of cardiovascular risk. Insulin sensitivity is related to the degree of physical activity, and physical training has been shown to ameliorate insulin action in insulin-resistant subjects. This effect is mediated by the improvement of the molecular abnormalities that are responsible of the insulin resistance, contributing in this way to restore the physiological insulin sensitivity. However, it should be underlined that mechanisms that account for this phenomenon are extremely complex and still unclear. Further studies are required to better clarify the molecular basis of the exercise-evoked improvement of insulin signal. [Figure: see text] |
format | Online Article Text |
id | pubmed-8043859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-80438592021-04-27 Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention Iaccarino, Guido Franco, Danilo Sorriento, Daniela Strisciuglio, Teresa Barbato, Emanuele Morisco, Carmine J Cardiovasc Transl Res Review The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the relevance of clinical evidence. In fact, several studies have documented the benefits of exercise training in the prevention of the cardiovascular risk. Abnormalities of insulin signaling transduction account for the impairment of insulin sensitivity and development of insulin resistance, which, in turn, is responsible for the enhancement of cardiovascular risk. Insulin sensitivity is related to the degree of physical activity, and physical training has been shown to ameliorate insulin action in insulin-resistant subjects. This effect is mediated by the improvement of the molecular abnormalities that are responsible of the insulin resistance, contributing in this way to restore the physiological insulin sensitivity. However, it should be underlined that mechanisms that account for this phenomenon are extremely complex and still unclear. Further studies are required to better clarify the molecular basis of the exercise-evoked improvement of insulin signal. [Figure: see text] Springer US 2020-07-31 2021 /pmc/articles/PMC8043859/ /pubmed/32737757 http://dx.doi.org/10.1007/s12265-020-10057-w Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Iaccarino, Guido Franco, Danilo Sorriento, Daniela Strisciuglio, Teresa Barbato, Emanuele Morisco, Carmine Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention |
title | Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention |
title_full | Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention |
title_fullStr | Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention |
title_full_unstemmed | Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention |
title_short | Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention |
title_sort | modulation of insulin sensitivity by exercise training: implications for cardiovascular prevention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043859/ https://www.ncbi.nlm.nih.gov/pubmed/32737757 http://dx.doi.org/10.1007/s12265-020-10057-w |
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