Cargando…

Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

The interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs) were investigated. Molecular docking using crystal structures of the ligand binding domains (LBDs) of LXRα and β revealed high docking scores for L3 and D3 hydroxymetabolites, similar to those of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Slominski, Andrzej T., Kim, Tae-Kang, Qayyum, Shariq, Song, Yuwei, Janjetovic, Zorica, Oak, Allen S. W., Slominski, Radomir M., Raman, Chander, Stefan, Joanna, Mier-Aguilar, Carlos A., Atigadda, Venkatram, Crossman, David K., Golub, Andriy, Bilokin, Yaroslav, Tang, Edith K. Y., Chen, Jake Y., Tuckey, Robert C., Jetten, Anton M., Song, Yuhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044163/ https://www.ncbi.nlm.nih.gov/pubmed/33850196 http://dx.doi.org/10.1038/s41598-021-87061-w

Ejemplares similares

RF15 | PMON293 Metabolic activation of tachysterol to biologically active hydroxyderivatives that act on VDR, AhR, LXRs and PPARγ receptors
por: Slominski, Andrzej, et al.
Publicado: (2022)

OR11-06 Biological Activity Of Lumisterol Hydroxymetabolites And Their Mechanism Of Action
por: Slominski, Andrzej T, et al.
Publicado: (2023)

Novel CYP11A1-Derived Vitamin D and Lumisterol Biometabolites for the Management of COVID-19
por: Qayyum, Shariq, et al.
Publicado: (2022)

Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols
por: Slominski, Andrzej T., et al.
Publicado: (2017)

Melatonin and Its Metabolites Can Serve as Agonists on the Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor Gamma
por: Slominski, Andrzej T., et al.
Publicado: (2023)

Vitamin D and Its Derivatives as Promising Drugs Against COVID-19 - A Computational Study
por: Song, Yuwei, et al.
Publicado: (2021)

Protective effects of novel derivatives of vitamin D(3) and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms
por: Chaiprasongsuk, Anyamanee, et al.
Publicado: (2019)

CYP11A1-derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas
por: Slominski, Andrzej T., et al.
Publicado: (2022)

Extra-adrenal glucocorticoid biosynthesis: Implications for autoimmune and inflammatory disorders.
por: Slominski, Radomir, et al.
Publicado: (2020)

Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey
por: Kim, Tae-Kang, et al.
Publicado: (2020)

Differential and Overlapping Effects of 20,23(OH)(2)D3 and 1,25(OH)(2)D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)(2)D3
por: Slominski, Andrzej T., et al.
Publicado: (2018)

CYP24A1 Expression Inversely Correlates with Melanoma Progression: Clinic-Pathological Studies
por: Brożyna, Anna A., et al.
Publicado: (2014)

Hydroxylumisterols, Photoproducts of Pre-Vitamin D3, Protect Human Keratinocytes against UVB-Induced Damage
por: Chaiprasongsuk, Anyamanee, et al.
Publicado: (2020)

Antitumor Effects of Vitamin D Analogs on Hamster and Mouse Melanoma Cell Lines in Relation to Melanin Pigmentation
por: Wasiewicz, Tomasz, et al.
Publicado: (2015)

Knocking out the Vitamin D Receptor Enhances Malignancy and Decreases Responsiveness to Vitamin D3 Hydroxyderivatives in Human Melanoma Cells
por: Podgorska, Ewa, et al.
Publicado: (2021)

Differential and Overlapping Effects of Melatonin and Its Metabolites on Keratinocyte Function: Bioinformatics and Metabolic Analyses
por: Stefan, Joanna, et al.
Publicado: (2021)

Protective Role of Melatonin and Its Metabolites in Skin Aging
por: Bocheva, Georgeta, et al.
Publicado: (2022)

Local Melatoninergic System as the Protector of Skin Integrity
por: Slominski, Andrzej T., et al.
Publicado: (2014)

Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness?
por: Slominski, Andrzej T., et al.
Publicado: (2020)

Sequential Metabolism of 7-Dehydrocholesterol to Steroidal 5,7-Dienes in Adrenal Glands and Its Biological Implication in the Skin
por: Slominski, Andrzej T., et al.
Publicado: (2009)

20-Hydroxycholecalciferol, Product of Vitamin D3 Hydroxylation by P450scc, Decreases NF-κB Activity by Increasing IκBα Levels in Human Keratinocytes
por: Janjetovic, Zorica, et al.
Publicado: (2009)

Current Molecular Markers of Melanoma and Treatment Targets
por: Yang, Kevin, et al.
Publicado: (2020)

Linking lipids, Alzheimer's and LXRs?
por: Patel, Nilay V., et al.
Publicado: (2004)

Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship
por: Slominski, Radomir M., et al.
Publicado: (2022)

Neuroendocrine Aspects of Skin Aging
por: Bocheva, Georgeta, et al.
Publicado: (2019)

The Impact of Vitamin D on Skin Aging
por: Bocheva, Georgeta, et al.
Publicado: (2021)

Environmental Air Pollutants Affecting Skin Functions with Systemic Implications
por: Bocheva, Georgeta, et al.
Publicado: (2023)

Immunological Aspects of Skin Aging in Atopic Dermatitis
por: Bocheva, Georgeta St., et al.
Publicado: (2021)

Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways
por: Janjetovic, Zorica, et al.
Publicado: (2017)

Cholesterol, Oxysterols and LXRs in Breast Cancer Pathophysiology
por: Nazih, Hassan, et al.
Publicado: (2020)

Investigation of 20S-hydroxyvitamin D(3) analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities
por: Lin, Zongtao, et al.
Publicado: (2018)

2349 The role of interleukin-23 in human melanoma
por: Jani, Aditi, et al.
Publicado: (2018)

Beyond the Foam Cell: The Role of LXRs in Preventing Atherogenesis
por: Rasheed, Adil, et al.
Publicado: (2018)

Revisiting the Role of LXRs in PUFA Metabolism and Phospholipid Homeostasis
por: Jalil, Antoine, et al.
Publicado: (2019)

PAGER Web APP: An Interactive, Online Gene Set and Network Interpretation Tool for Functional Genomics
por: Yue, Zongliang, et al.
Publicado: (2022)

Novel vitamin D photoproducts and their precursors in the skin
por: Slominski, Andrzej, et al.
Publicado: (2013)

1α,20S-Dihydroxyvitamin D(3) Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis
por: Lin, Zongtao, et al.
Publicado: (2017)

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives
por: Janjetovic, Z, et al.
Publicado: (2011)

Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy
por: Brożyna, Anna A., et al.
Publicado: (2022)

Products of Vitamin D3 or 7-Dehydrocholesterol Metabolism by Cytochrome P450scc Show Anti-Leukemia Effects, Having Low or Absent Calcemic Activity
por: Slominski, Andrzej T., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_fihju11m7b3n2hvhp3p79u0gj9