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Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target

An accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state Li target can achieve sufficient neutron flux for treatment although the neutron flux is reduced over the lifetime of its target. In this study, the reduction was examined in the five targets, and a model was th...

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Autores principales: Nakamura, Satoshi, Igaki, Hiroshi, Ito, Masashi, Imamichi, Shoji, Kashihara, Tairo, Okamoto, Hiroyuki, Nishioka, Shie, Iijima, Kotaro, Chiba, Takahito, Nakayama, Hiroki, Takemori, Mihiro, Abe, Yoshihisa, Kaneda, Tomoya, Takahashi, Kana, Inaba, Koji, Okuma, Kae, Murakami, Naoya, Nakayama, Yuko, Masutani, Mitsuko, Nishio, Teiji, Itami, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044165/
https://www.ncbi.nlm.nih.gov/pubmed/33850253
http://dx.doi.org/10.1038/s41598-021-87627-8
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author Nakamura, Satoshi
Igaki, Hiroshi
Ito, Masashi
Imamichi, Shoji
Kashihara, Tairo
Okamoto, Hiroyuki
Nishioka, Shie
Iijima, Kotaro
Chiba, Takahito
Nakayama, Hiroki
Takemori, Mihiro
Abe, Yoshihisa
Kaneda, Tomoya
Takahashi, Kana
Inaba, Koji
Okuma, Kae
Murakami, Naoya
Nakayama, Yuko
Masutani, Mitsuko
Nishio, Teiji
Itami, Jun
author_facet Nakamura, Satoshi
Igaki, Hiroshi
Ito, Masashi
Imamichi, Shoji
Kashihara, Tairo
Okamoto, Hiroyuki
Nishioka, Shie
Iijima, Kotaro
Chiba, Takahito
Nakayama, Hiroki
Takemori, Mihiro
Abe, Yoshihisa
Kaneda, Tomoya
Takahashi, Kana
Inaba, Koji
Okuma, Kae
Murakami, Naoya
Nakayama, Yuko
Masutani, Mitsuko
Nishio, Teiji
Itami, Jun
author_sort Nakamura, Satoshi
collection PubMed
description An accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state Li target can achieve sufficient neutron flux for treatment although the neutron flux is reduced over the lifetime of its target. In this study, the reduction was examined in the five targets, and a model was then established to represent the neutron flux. In each target, a reduction in neutron flux was observed based on the integrated proton charge on the target, and its reduction reached 28% after the integrated proton charge of 2.52 × 10(6) mC was delivered to the target in the system. The calculated neutron flux acquired by the model was compared to the measured neutron flux based on an integrated proton charge, and the mean discrepancies were less than 0.1% in all the targets investigated. These discrepancies were comparable among the five targets examined. Thus, the reduction of the neutron flux can be represented by the model. Additionally, by adequately revising the model, it may be applicable to other BNCT systems employing a Li target, thus furthering research in this direction. Therefore, the established model will play an important role in the accelerator-based BNCT system with a solid-state Li target in controlling neutron delivery and understanding the neutron output characteristics.
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spelling pubmed-80441652021-04-14 Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target Nakamura, Satoshi Igaki, Hiroshi Ito, Masashi Imamichi, Shoji Kashihara, Tairo Okamoto, Hiroyuki Nishioka, Shie Iijima, Kotaro Chiba, Takahito Nakayama, Hiroki Takemori, Mihiro Abe, Yoshihisa Kaneda, Tomoya Takahashi, Kana Inaba, Koji Okuma, Kae Murakami, Naoya Nakayama, Yuko Masutani, Mitsuko Nishio, Teiji Itami, Jun Sci Rep Article An accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state Li target can achieve sufficient neutron flux for treatment although the neutron flux is reduced over the lifetime of its target. In this study, the reduction was examined in the five targets, and a model was then established to represent the neutron flux. In each target, a reduction in neutron flux was observed based on the integrated proton charge on the target, and its reduction reached 28% after the integrated proton charge of 2.52 × 10(6) mC was delivered to the target in the system. The calculated neutron flux acquired by the model was compared to the measured neutron flux based on an integrated proton charge, and the mean discrepancies were less than 0.1% in all the targets investigated. These discrepancies were comparable among the five targets examined. Thus, the reduction of the neutron flux can be represented by the model. Additionally, by adequately revising the model, it may be applicable to other BNCT systems employing a Li target, thus furthering research in this direction. Therefore, the established model will play an important role in the accelerator-based BNCT system with a solid-state Li target in controlling neutron delivery and understanding the neutron output characteristics. Nature Publishing Group UK 2021-04-13 /pmc/articles/PMC8044165/ /pubmed/33850253 http://dx.doi.org/10.1038/s41598-021-87627-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nakamura, Satoshi
Igaki, Hiroshi
Ito, Masashi
Imamichi, Shoji
Kashihara, Tairo
Okamoto, Hiroyuki
Nishioka, Shie
Iijima, Kotaro
Chiba, Takahito
Nakayama, Hiroki
Takemori, Mihiro
Abe, Yoshihisa
Kaneda, Tomoya
Takahashi, Kana
Inaba, Koji
Okuma, Kae
Murakami, Naoya
Nakayama, Yuko
Masutani, Mitsuko
Nishio, Teiji
Itami, Jun
Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target
title Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target
title_full Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target
title_fullStr Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target
title_full_unstemmed Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target
title_short Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target
title_sort neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044165/
https://www.ncbi.nlm.nih.gov/pubmed/33850253
http://dx.doi.org/10.1038/s41598-021-87627-8
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