Calcium bilirubinate sludge causes early onset of congenital biliary dilatation: a report of two cases

BACKGROUND: Symptomatic congenital biliary dilatation (CBD) during early infancy is always characterized by cystic dilation of the common bile duct with a narrow segment connecting the pancreatic duct. CASE PRESENTATION: In two consecutive infants with a prenatal diagnosis of CBD, we found that bili...

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Detalles Bibliográficos
Autores principales: Kato, Shoko, Kaneko, Kenitiro, Matsushita, Nozomi, Kurahashi, Shintaro, Osawa, Takaaki, Matsumura, Tatsuki, Saito, Takuya, Fukami, Yasuyuki, Komatsu, Shunichiro, Sano, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044275/
https://www.ncbi.nlm.nih.gov/pubmed/33851282
http://dx.doi.org/10.1186/s40792-021-01175-x
Descripción
Sumario:BACKGROUND: Symptomatic congenital biliary dilatation (CBD) during early infancy is always characterized by cystic dilation of the common bile duct with a narrow segment connecting the pancreatic duct. CASE PRESENTATION: In two consecutive infants with a prenatal diagnosis of CBD, we found that biliary sludge had formed in the cyst upon the appearance of symptoms including acholic stool and hypertransaminasemia. Infrared absorption spectrometry revealed that the sludge consisted of calcium bilirubinate. CONCLUSION: We suggest that overproduction of bilirubin by neonatal hemolysis causes sedimentation of bilirubin calcium, resulting in obstruction of the narrow segment and development of symptoms.

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