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Inducible ablation of CD11c(+) cells to determine their role in skin wound repair

Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound clos...

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Detalles Bibliográficos
Autores principales: Li, Zhi, Lamb, Rebecca, Coles, Mark C., Bennett, Clare L., Ambler, Carrie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044329/
https://www.ncbi.nlm.nih.gov/pubmed/33502012
http://dx.doi.org/10.1111/imm.13312
Descripción
Sumario:Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.[Image: see text]