Inducible ablation of CD11c(+) cells to determine their role in skin wound repair

Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound clos...

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Autores principales: Li, Zhi, Lamb, Rebecca, Coles, Mark C., Bennett, Clare L., Ambler, Carrie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044329/
https://www.ncbi.nlm.nih.gov/pubmed/33502012
http://dx.doi.org/10.1111/imm.13312
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author Li, Zhi
Lamb, Rebecca
Coles, Mark C.
Bennett, Clare L.
Ambler, Carrie A.
author_facet Li, Zhi
Lamb, Rebecca
Coles, Mark C.
Bennett, Clare L.
Ambler, Carrie A.
author_sort Li, Zhi
collection PubMed
description Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.[Image: see text]
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spelling pubmed-80443292021-04-16 Inducible ablation of CD11c(+) cells to determine their role in skin wound repair Li, Zhi Lamb, Rebecca Coles, Mark C. Bennett, Clare L. Ambler, Carrie A. Immunology Commentary Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.[Image: see text] John Wiley and Sons Inc. 2021-03-01 2021-05 /pmc/articles/PMC8044329/ /pubmed/33502012 http://dx.doi.org/10.1111/imm.13312 Text en © 2021 The Authors. Immunology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Li, Zhi
Lamb, Rebecca
Coles, Mark C.
Bennett, Clare L.
Ambler, Carrie A.
Inducible ablation of CD11c(+) cells to determine their role in skin wound repair
title Inducible ablation of CD11c(+) cells to determine their role in skin wound repair
title_full Inducible ablation of CD11c(+) cells to determine their role in skin wound repair
title_fullStr Inducible ablation of CD11c(+) cells to determine their role in skin wound repair
title_full_unstemmed Inducible ablation of CD11c(+) cells to determine their role in skin wound repair
title_short Inducible ablation of CD11c(+) cells to determine their role in skin wound repair
title_sort inducible ablation of cd11c(+) cells to determine their role in skin wound repair
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044329/
https://www.ncbi.nlm.nih.gov/pubmed/33502012
http://dx.doi.org/10.1111/imm.13312
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