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Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance
Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic stem cell transplant recipients that is associated with high morbidity and mortality rates. The worldwide emergence of antimicrobial resistance is of special concern in this population because any delay in starti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044357/ https://www.ncbi.nlm.nih.gov/pubmed/33869250 http://dx.doi.org/10.3389/fmed.2021.636547 |
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author | Gudiol, Carlota Albasanz-Puig, Adaia Cuervo, Guillermo Carratalà, Jordi |
author_facet | Gudiol, Carlota Albasanz-Puig, Adaia Cuervo, Guillermo Carratalà, Jordi |
author_sort | Gudiol, Carlota |
collection | PubMed |
description | Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic stem cell transplant recipients that is associated with high morbidity and mortality rates. The worldwide emergence of antimicrobial resistance is of special concern in this population because any delay in starting adequate empirical antibiotic therapy can lead to poor outcomes. In this review, we aim to address: (1) the mechanisms involved in the development of sepsis and septic shock in these patients; (2) the risk factors associated with a worse prognosis; (3) the impact of adequate initial empirical antibiotic therapy given the current era of widespread antimicrobial resistance; and (4) the optimal management of sepsis, including adequate and early source control of infection, optimized antibiotic use based on the pharmacokinetic and pharmacodynamics changes in these patients, and the role of the new available antibiotics. |
format | Online Article Text |
id | pubmed-8044357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80443572021-04-15 Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance Gudiol, Carlota Albasanz-Puig, Adaia Cuervo, Guillermo Carratalà, Jordi Front Med (Lausanne) Medicine Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic stem cell transplant recipients that is associated with high morbidity and mortality rates. The worldwide emergence of antimicrobial resistance is of special concern in this population because any delay in starting adequate empirical antibiotic therapy can lead to poor outcomes. In this review, we aim to address: (1) the mechanisms involved in the development of sepsis and septic shock in these patients; (2) the risk factors associated with a worse prognosis; (3) the impact of adequate initial empirical antibiotic therapy given the current era of widespread antimicrobial resistance; and (4) the optimal management of sepsis, including adequate and early source control of infection, optimized antibiotic use based on the pharmacokinetic and pharmacodynamics changes in these patients, and the role of the new available antibiotics. Frontiers Media S.A. 2021-03-31 /pmc/articles/PMC8044357/ /pubmed/33869250 http://dx.doi.org/10.3389/fmed.2021.636547 Text en Copyright © 2021 Gudiol, Albasanz-Puig, Cuervo and Carratalà. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Gudiol, Carlota Albasanz-Puig, Adaia Cuervo, Guillermo Carratalà, Jordi Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance |
title | Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance |
title_full | Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance |
title_fullStr | Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance |
title_full_unstemmed | Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance |
title_short | Understanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial Resistance |
title_sort | understanding and managing sepsis in patients with cancer in the era of antimicrobial resistance |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044357/ https://www.ncbi.nlm.nih.gov/pubmed/33869250 http://dx.doi.org/10.3389/fmed.2021.636547 |
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