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γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance. Recently, accumulating researches have highlighted the crosst...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044362/ https://www.ncbi.nlm.nih.gov/pubmed/33868300 http://dx.doi.org/10.3389/fimmu.2021.656097 |
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author | Li, Yunxuan Zhang, Yixi Zeng, Xun |
author_facet | Li, Yunxuan Zhang, Yixi Zeng, Xun |
author_sort | Li, Yunxuan |
collection | PubMed |
description | γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance. Recently, accumulating researches have highlighted the crosstalk between γδ T cells and nervous systems. In these reports, γδ T cells maintain some physiological functions of central nervous system by secreting interleukin (IL) 17, and neurons like nociceptors can in turn regulate the activity of γδ T cells. Moreover, γδ T cells are involved in neuroinflammation such as stroke and multiple sclerosis. This review illustrates the relationship between γδ T cells and nervous systems in physiological and pathological conditions. |
format | Online Article Text |
id | pubmed-8044362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80443622021-04-15 γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde Li, Yunxuan Zhang, Yixi Zeng, Xun Front Immunol Immunology γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance. Recently, accumulating researches have highlighted the crosstalk between γδ T cells and nervous systems. In these reports, γδ T cells maintain some physiological functions of central nervous system by secreting interleukin (IL) 17, and neurons like nociceptors can in turn regulate the activity of γδ T cells. Moreover, γδ T cells are involved in neuroinflammation such as stroke and multiple sclerosis. This review illustrates the relationship between γδ T cells and nervous systems in physiological and pathological conditions. Frontiers Media S.A. 2021-03-31 /pmc/articles/PMC8044362/ /pubmed/33868300 http://dx.doi.org/10.3389/fimmu.2021.656097 Text en Copyright © 2021 Li, Zhang and Zeng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Li, Yunxuan Zhang, Yixi Zeng, Xun γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde |
title | γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde |
title_full | γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde |
title_fullStr | γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde |
title_full_unstemmed | γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde |
title_short | γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde |
title_sort | γδ t cells participating in nervous systems: a story of jekyll and hyde |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044362/ https://www.ncbi.nlm.nih.gov/pubmed/33868300 http://dx.doi.org/10.3389/fimmu.2021.656097 |
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