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γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde

γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance. Recently, accumulating researches have highlighted the crosst...

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Detalles Bibliográficos
Autores principales: Li, Yunxuan, Zhang, Yixi, Zeng, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044362/
https://www.ncbi.nlm.nih.gov/pubmed/33868300
http://dx.doi.org/10.3389/fimmu.2021.656097
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author Li, Yunxuan
Zhang, Yixi
Zeng, Xun
author_facet Li, Yunxuan
Zhang, Yixi
Zeng, Xun
author_sort Li, Yunxuan
collection PubMed
description γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance. Recently, accumulating researches have highlighted the crosstalk between γδ T cells and nervous systems. In these reports, γδ T cells maintain some physiological functions of central nervous system by secreting interleukin (IL) 17, and neurons like nociceptors can in turn regulate the activity of γδ T cells. Moreover, γδ T cells are involved in neuroinflammation such as stroke and multiple sclerosis. This review illustrates the relationship between γδ T cells and nervous systems in physiological and pathological conditions.
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spelling pubmed-80443622021-04-15 γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde Li, Yunxuan Zhang, Yixi Zeng, Xun Front Immunol Immunology γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance. Recently, accumulating researches have highlighted the crosstalk between γδ T cells and nervous systems. In these reports, γδ T cells maintain some physiological functions of central nervous system by secreting interleukin (IL) 17, and neurons like nociceptors can in turn regulate the activity of γδ T cells. Moreover, γδ T cells are involved in neuroinflammation such as stroke and multiple sclerosis. This review illustrates the relationship between γδ T cells and nervous systems in physiological and pathological conditions. Frontiers Media S.A. 2021-03-31 /pmc/articles/PMC8044362/ /pubmed/33868300 http://dx.doi.org/10.3389/fimmu.2021.656097 Text en Copyright © 2021 Li, Zhang and Zeng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Yunxuan
Zhang, Yixi
Zeng, Xun
γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
title γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
title_full γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
title_fullStr γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
title_full_unstemmed γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
title_short γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
title_sort γδ t cells participating in nervous systems: a story of jekyll and hyde
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044362/
https://www.ncbi.nlm.nih.gov/pubmed/33868300
http://dx.doi.org/10.3389/fimmu.2021.656097
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