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Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior

The preoptic area (POA) has long been recognized as a sleep center, first proposed by von Economo. The POA, especially the medial POA (MPOA), is also involved in the regulation of various innate functions such as sexual and parental behaviors. Consistent with its many roles, the MPOA is composed of...

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Autores principales: Tsuneoka, Yousuke, Funato, Hiromasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044373/
https://www.ncbi.nlm.nih.gov/pubmed/33867927
http://dx.doi.org/10.3389/fnins.2021.649159
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author Tsuneoka, Yousuke
Funato, Hiromasa
author_facet Tsuneoka, Yousuke
Funato, Hiromasa
author_sort Tsuneoka, Yousuke
collection PubMed
description The preoptic area (POA) has long been recognized as a sleep center, first proposed by von Economo. The POA, especially the medial POA (MPOA), is also involved in the regulation of various innate functions such as sexual and parental behaviors. Consistent with its many roles, the MPOA is composed of subregions that are identified by different gene and protein expressions. This review addresses the current understanding of the molecular and cellular architecture of POA neurons in relation to sleep and reproductive behavior. Optogenetic and pharmacogenetic studies have revealed a diverse group of neurons within the POA that exhibit different neural activity patterns depending on vigilance states and whose activity can enhance or suppress wake, non-rapid eye movement (NREM) sleep, or rapid eye movement (REM) sleep. These sleep-regulating neurons are not restricted to the ventrolateral POA (VLPO) region but are widespread in the lateral MPOA and LPOA as well. Neurons expressing galanin also express gonadal steroid receptors and regulate motivational aspects of reproductive behaviors. Moxd1, a novel marker of sexually dimorphic nuclei (SDN), visualizes the SDN of the POA (SDN-POA). The role of the POA in sleep and other innate behaviors has been addressed separately; more integrated observation will be necessary to obtain physiologically relevant insight that penetrates the different dimensions of animal behavior.
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spelling pubmed-80443732021-04-15 Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior Tsuneoka, Yousuke Funato, Hiromasa Front Neurosci Neuroscience The preoptic area (POA) has long been recognized as a sleep center, first proposed by von Economo. The POA, especially the medial POA (MPOA), is also involved in the regulation of various innate functions such as sexual and parental behaviors. Consistent with its many roles, the MPOA is composed of subregions that are identified by different gene and protein expressions. This review addresses the current understanding of the molecular and cellular architecture of POA neurons in relation to sleep and reproductive behavior. Optogenetic and pharmacogenetic studies have revealed a diverse group of neurons within the POA that exhibit different neural activity patterns depending on vigilance states and whose activity can enhance or suppress wake, non-rapid eye movement (NREM) sleep, or rapid eye movement (REM) sleep. These sleep-regulating neurons are not restricted to the ventrolateral POA (VLPO) region but are widespread in the lateral MPOA and LPOA as well. Neurons expressing galanin also express gonadal steroid receptors and regulate motivational aspects of reproductive behaviors. Moxd1, a novel marker of sexually dimorphic nuclei (SDN), visualizes the SDN of the POA (SDN-POA). The role of the POA in sleep and other innate behaviors has been addressed separately; more integrated observation will be necessary to obtain physiologically relevant insight that penetrates the different dimensions of animal behavior. Frontiers Media S.A. 2021-03-31 /pmc/articles/PMC8044373/ /pubmed/33867927 http://dx.doi.org/10.3389/fnins.2021.649159 Text en Copyright © 2021 Tsuneoka and Funato. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tsuneoka, Yousuke
Funato, Hiromasa
Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior
title Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior
title_full Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior
title_fullStr Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior
title_full_unstemmed Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior
title_short Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior
title_sort cellular composition of the preoptic area regulating sleep, parental, and sexual behavior
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044373/
https://www.ncbi.nlm.nih.gov/pubmed/33867927
http://dx.doi.org/10.3389/fnins.2021.649159
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