Cargando…

Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response

Cellular homeostasis is governed by the precise expression of genes that control the translation, localization, and termination of proteins. Oftentimes, environmental and biological factors can introduce mutations into the genetic framework of cells during their growth and division, and these geneti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mathieu, Nicholas A., Levin, Rafael H., Spratt, Donald E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044464/ https://www.ncbi.nlm.nih.gov/pubmed/33869064 http://dx.doi.org/10.3389/fonc.2021.659049

Ejemplares similares

The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration
por: Haouari, Shanez, et al.
Publicado: (2022)

Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4
por: Aerne, Birgit L., et al.
Publicado: (2015)

Redefining the catalytic HECT domain boundaries for the HECT E3 ubiquitin ligase family
por: Kane, Emma I., et al.
Publicado: (2022)

HERC Ubiquitin Ligases in Cancer
por: Sala-Gaston, Joan, et al.
Publicado: (2020)

HERCing: Structural and Functional Relevance of the Large HERC Ubiquitin Ligases
por: García-Cano, Jesús, et al.
Publicado: (2019)

Evolution of Plant HECT Ubiquitin Ligases
por: Marín, Ignacio
Publicado: (2013)

Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer
por: Sun, Aiqin, et al.
Publicado: (2023)

Regulation of the MDM2‐p53 pathway by the ubiquitin ligase HERC2
por: García‐Cano, Jesús, et al.
Publicado: (2019)

Origin and evolution of fungal HECT ubiquitin ligases
por: Marín, Ignacio
Publicado: (2018)

Crystal structure of the catalytic C‐lobe of the HECT‐type ubiquitin ligase E6AP
por: Ries, Lena K., et al.
Publicado: (2020)

Animal HECT ubiquitin ligases: evolution and functional implications
por: Marín, Ignacio
Publicado: (2010)

HECT ubiquitin ligases as accessory proteins of the plant proteasome
por: Wang, Zhishuo, et al.
Publicado: (2022)

The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner
por: Ali, Muhammad Shahzad, et al.
Publicado: (2021)

HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory
por: Pérez-Villegas, Eva M., et al.
Publicado: (2020)

Regulation of MAPK Signaling Pathways by the Large HERC Ubiquitin Ligases
por: Sala-Gaston, Joan, et al.
Publicado: (2023)

Rescue of HIV-1 Release by Targeting Widely Divergent NEDD4-Type Ubiquitin Ligases and Isolated Catalytic HECT Domains to Gag
por: Weiss, Eric R., et al.
Publicado: (2010)

Activity‐Based Probes for HECT E3 Ubiquitin Ligases
por: Byrne, Robert, et al.
Publicado: (2017)

The Role of HECT E3 Ubiquitin Ligases in Colorectal Cancer
por: Sun, Aiqin, et al.
Publicado: (2023)

The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives
por: Zhang, Rui, et al.
Publicado: (2023)

Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
por: Xie, Shangdan, et al.
Publicado: (2021)

A Genomic Survey of HECT Ubiquitin Ligases in Eukaryotes Reveals Independent Expansions of the HECT System in Several Lineages
por: Grau-Bové, Xavier, et al.
Publicado: (2013)

(1)H, (13)C, and (15)N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH
por: Beasley, Steven A., et al.
Publicado: (2018)

Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase
por: Spratt, Donald E., et al.
Publicado: (2013)

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
por: Riley, B.E., et al.
Publicado: (2013)

The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function
por: He, Shan, et al.
Publicado: (2017)

Proteomic Analysis and Identification of Cellular Interactors of the Giant Ubiquitin Ligase HERC2
por: Galligan, Jeffrey T., et al.
Publicado: (2014)

The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination
por: Cubillos-Rojas, Monica, et al.
Publicado: (2016)

The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses
por: Montes-Fernández, Mª Angeles, et al.
Publicado: (2020)

An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity
por: Beasley, Steven A., et al.
Publicado: (2020)

Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled
por: Mund, Thomas, et al.
Publicado: (2015)

Evidence of an Antimicrobial Peptide Signature Encrypted in HECT E3 Ubiquitin Ligases
por: Candido-Ferreira, Ivan Lavander, et al.
Publicado: (2017)

Proteasome-associated HECT-type ubiquitin ligase activity is required for plant immunity
por: Furniss, James J., et al.
Publicado: (2018)

Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress
por: Qian, Hao, et al.
Publicado: (2020)

Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation
por: Melino, Gerry, et al.
Publicado: (2019)

Emerging roles of the HECT-type E3 ubiquitin ligases in hematological malignancies
por: Delvecchio, Vincenza Simona, et al.
Publicado: (2021)

CRL Ubiquitin Ligases and DNA Damage Response
por: Li, Ju-Mei, et al.
Publicado: (2012)

Ubiquitination of alpha-synuclein filaments by Nedd4 ligases
por: Mund, Thomas, et al.
Publicado: (2018)

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response
por: Mathieu, Nicholas A., et al.
Publicado: (2021)

The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation
por: Xu, Yue, et al.
Publicado: (2016)

Substrate clustering potently regulates the activity of WW-HECT domain–containing ubiquitin ligases
por: Mund, Thomas, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_scnkg793uc2g3t9mfgsn66aedm