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Myocardial Infarction in Systemic Lupus Erythematosus: Incidence and Coronary Angiography Findings

An association between acute myocardial infarction (AMI) and systemic lupus erythematosus (SLE) has been suggested. The cause of AMI is presumed to be atherothrombosis. In the present study, the primary objective was to assess incident AMI cases and the secondary objective was to estimate the propor...

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Autores principales: Tornvall, Per, Göransson, Alexandra, Ekman, Julia, Järnbert-Pettersson, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044619/
https://www.ncbi.nlm.nih.gov/pubmed/33412909
http://dx.doi.org/10.1177/0003319720985337
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author Tornvall, Per
Göransson, Alexandra
Ekman, Julia
Järnbert-Pettersson, Hans
author_facet Tornvall, Per
Göransson, Alexandra
Ekman, Julia
Järnbert-Pettersson, Hans
author_sort Tornvall, Per
collection PubMed
description An association between acute myocardial infarction (AMI) and systemic lupus erythematosus (SLE) has been suggested. The cause of AMI is presumed to be atherothrombosis. In the present study, the primary objective was to assess incident AMI cases and the secondary objective was to estimate the proportion of myocardial infarction with nonobstructive coronary arteries (MINOCA) in patients with SLE. All Swedish patients with SLE without AMI before 1996 (n = 4192) were followed for 20 years in the national patient registry. For each SLE patient, 10 age- and sex-matched controls without SLE and AMI before 1996 (n = 41 892) were identified. Data from patients and controls with AMI after 1996 were linked with the Swedish coronary angiography and angioplasty register; 549 (13%) and 3352 (8%) first AMIs occurred in patients with SLE and controls, respectively. The incidence of AMI was 9.6 (95% CI: 8.9-10.5) and 4.9 (95% CI: 4.8-5.1) events/1000 person-years in patients with SLE and controls, respectively. The proportion of MINOCA was 10.8% in patients with SLE and 13.8% in controls (P = .261), respectively. In conclusion, the incidence of AMI is increased in a European population of patients with SLE but there is no indication that the proportion of MINOCA is increased in these patients.
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spelling pubmed-80446192021-04-22 Myocardial Infarction in Systemic Lupus Erythematosus: Incidence and Coronary Angiography Findings Tornvall, Per Göransson, Alexandra Ekman, Julia Järnbert-Pettersson, Hans Angiology Coronary Artery Disease in Systemic Lupus Erythematosus An association between acute myocardial infarction (AMI) and systemic lupus erythematosus (SLE) has been suggested. The cause of AMI is presumed to be atherothrombosis. In the present study, the primary objective was to assess incident AMI cases and the secondary objective was to estimate the proportion of myocardial infarction with nonobstructive coronary arteries (MINOCA) in patients with SLE. All Swedish patients with SLE without AMI before 1996 (n = 4192) were followed for 20 years in the national patient registry. For each SLE patient, 10 age- and sex-matched controls without SLE and AMI before 1996 (n = 41 892) were identified. Data from patients and controls with AMI after 1996 were linked with the Swedish coronary angiography and angioplasty register; 549 (13%) and 3352 (8%) first AMIs occurred in patients with SLE and controls, respectively. The incidence of AMI was 9.6 (95% CI: 8.9-10.5) and 4.9 (95% CI: 4.8-5.1) events/1000 person-years in patients with SLE and controls, respectively. The proportion of MINOCA was 10.8% in patients with SLE and 13.8% in controls (P = .261), respectively. In conclusion, the incidence of AMI is increased in a European population of patients with SLE but there is no indication that the proportion of MINOCA is increased in these patients. SAGE Publications 2021-01-08 2021-05 /pmc/articles/PMC8044619/ /pubmed/33412909 http://dx.doi.org/10.1177/0003319720985337 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Coronary Artery Disease in Systemic Lupus Erythematosus
Tornvall, Per
Göransson, Alexandra
Ekman, Julia
Järnbert-Pettersson, Hans
Myocardial Infarction in Systemic Lupus Erythematosus: Incidence and Coronary Angiography Findings
title Myocardial Infarction in Systemic Lupus Erythematosus: Incidence and Coronary Angiography Findings
title_full Myocardial Infarction in Systemic Lupus Erythematosus: Incidence and Coronary Angiography Findings
title_fullStr Myocardial Infarction in Systemic Lupus Erythematosus: Incidence and Coronary Angiography Findings
title_full_unstemmed Myocardial Infarction in Systemic Lupus Erythematosus: Incidence and Coronary Angiography Findings
title_short Myocardial Infarction in Systemic Lupus Erythematosus: Incidence and Coronary Angiography Findings
title_sort myocardial infarction in systemic lupus erythematosus: incidence and coronary angiography findings
topic Coronary Artery Disease in Systemic Lupus Erythematosus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044619/
https://www.ncbi.nlm.nih.gov/pubmed/33412909
http://dx.doi.org/10.1177/0003319720985337
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