Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma

Exosomes are small extracellular vesicles secreted by most somatic cells, which can carry a variety of biologically active substances to participate in intercellular communication and regulate the pathophysiological process of recipient cells. Recent studies have confirmed that non-coding RNAs (ncRN...

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Autores principales: Xia, Haoming, Huang, Ziyue, Liu, Shuqiang, Zhao, Xudong, He, Risheng, Wang, Zhongrui, Shi, Wenguang, Chen, Wangming, Li, Zhizhou, Yu, Liang, Huang, Peng, Kang, Pengcheng, Su, Zhilei, Xu, Yi, Yam, Judy Wai Ping, Cui, Yunfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044750/
https://www.ncbi.nlm.nih.gov/pubmed/33869059
http://dx.doi.org/10.3389/fonc.2021.653846
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author Xia, Haoming
Huang, Ziyue
Liu, Shuqiang
Zhao, Xudong
He, Risheng
Wang, Zhongrui
Shi, Wenguang
Chen, Wangming
Li, Zhizhou
Yu, Liang
Huang, Peng
Kang, Pengcheng
Su, Zhilei
Xu, Yi
Yam, Judy Wai Ping
Cui, Yunfu
author_facet Xia, Haoming
Huang, Ziyue
Liu, Shuqiang
Zhao, Xudong
He, Risheng
Wang, Zhongrui
Shi, Wenguang
Chen, Wangming
Li, Zhizhou
Yu, Liang
Huang, Peng
Kang, Pengcheng
Su, Zhilei
Xu, Yi
Yam, Judy Wai Ping
Cui, Yunfu
author_sort Xia, Haoming
collection PubMed
description Exosomes are small extracellular vesicles secreted by most somatic cells, which can carry a variety of biologically active substances to participate in intercellular communication and regulate the pathophysiological process of recipient cells. Recent studies have confirmed that non-coding RNAs (ncRNAs) carried by tumor cell/non-tumor cell-derived exosomes have the function of regulating the cancerous derivation of target cells and remodeling the tumor microenvironment (TME). In addition, due to the unique low immunogenicity and high stability, exosomes can be used as natural vehicles for the delivery of therapeutic ncRNAs in vivo. This article aims to review the potential regulatory mechanism and the therapeutic value of exosomal ncRNAs in hepatocellular carcinoma (HCC), in order to provide promising targets for early diagnosis and precise therapy of HCC.
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spelling pubmed-80447502021-04-15 Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma Xia, Haoming Huang, Ziyue Liu, Shuqiang Zhao, Xudong He, Risheng Wang, Zhongrui Shi, Wenguang Chen, Wangming Li, Zhizhou Yu, Liang Huang, Peng Kang, Pengcheng Su, Zhilei Xu, Yi Yam, Judy Wai Ping Cui, Yunfu Front Oncol Oncology Exosomes are small extracellular vesicles secreted by most somatic cells, which can carry a variety of biologically active substances to participate in intercellular communication and regulate the pathophysiological process of recipient cells. Recent studies have confirmed that non-coding RNAs (ncRNAs) carried by tumor cell/non-tumor cell-derived exosomes have the function of regulating the cancerous derivation of target cells and remodeling the tumor microenvironment (TME). In addition, due to the unique low immunogenicity and high stability, exosomes can be used as natural vehicles for the delivery of therapeutic ncRNAs in vivo. This article aims to review the potential regulatory mechanism and the therapeutic value of exosomal ncRNAs in hepatocellular carcinoma (HCC), in order to provide promising targets for early diagnosis and precise therapy of HCC. Frontiers Media S.A. 2021-03-26 /pmc/articles/PMC8044750/ /pubmed/33869059 http://dx.doi.org/10.3389/fonc.2021.653846 Text en Copyright © 2021 Xia, Huang, Liu, Zhao, He, Wang, Shi, Chen, Li, Yu, Huang, Kang, Su, Xu, Yam and Cui https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xia, Haoming
Huang, Ziyue
Liu, Shuqiang
Zhao, Xudong
He, Risheng
Wang, Zhongrui
Shi, Wenguang
Chen, Wangming
Li, Zhizhou
Yu, Liang
Huang, Peng
Kang, Pengcheng
Su, Zhilei
Xu, Yi
Yam, Judy Wai Ping
Cui, Yunfu
Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma
title Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma
title_full Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma
title_fullStr Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma
title_full_unstemmed Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma
title_short Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma
title_sort exosomal non-coding rnas: regulatory and therapeutic target of hepatocellular carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044750/
https://www.ncbi.nlm.nih.gov/pubmed/33869059
http://dx.doi.org/10.3389/fonc.2021.653846
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