Case Report: Central Nervous System Immune Reconstitution Inflammatory Syndrome Related to Bacterial Meningitis

Central nervous system immune reconstitution inflammatory syndrome (CNS-IRIS) describes clinical characteristics that may be observed in previously immunocompromised patients during rapid restoration of immunity function in the presence of a pathogen. There have been no reports about CNS-IRIS relate...

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Autores principales: Hu, Mengyan, Liu, Sanxin, Lu, Danli, Zhong, Yi, Yu, Dafan, Qiu, Wei, Lu, Zhengqi, Zhang, Bingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044765/
https://www.ncbi.nlm.nih.gov/pubmed/33868222
http://dx.doi.org/10.3389/fimmu.2021.585316
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author Hu, Mengyan
Liu, Sanxin
Lu, Danli
Zhong, Yi
Yu, Dafan
Qiu, Wei
Lu, Zhengqi
Zhang, Bingjun
author_facet Hu, Mengyan
Liu, Sanxin
Lu, Danli
Zhong, Yi
Yu, Dafan
Qiu, Wei
Lu, Zhengqi
Zhang, Bingjun
author_sort Hu, Mengyan
collection PubMed
description Central nervous system immune reconstitution inflammatory syndrome (CNS-IRIS) describes clinical characteristics that may be observed in previously immunocompromised patients during rapid restoration of immunity function in the presence of a pathogen. There have been no reports about CNS-IRIS related to bacterial meningitis so far. Here, we report a 24-year-old pregnant female patient with bacterial meningitis. Her clinical and neuroradiological condition worsened after induced labor despite great effective anti-infective therapy. CNS-IRIS was considered. Corticosteroids were administered, and the patient gradually recovered. We present the first case of CNS-IRIS associated with bacterial meningitis.
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spelling pubmed-80447652021-04-15 Case Report: Central Nervous System Immune Reconstitution Inflammatory Syndrome Related to Bacterial Meningitis Hu, Mengyan Liu, Sanxin Lu, Danli Zhong, Yi Yu, Dafan Qiu, Wei Lu, Zhengqi Zhang, Bingjun Front Immunol Immunology Central nervous system immune reconstitution inflammatory syndrome (CNS-IRIS) describes clinical characteristics that may be observed in previously immunocompromised patients during rapid restoration of immunity function in the presence of a pathogen. There have been no reports about CNS-IRIS related to bacterial meningitis so far. Here, we report a 24-year-old pregnant female patient with bacterial meningitis. Her clinical and neuroradiological condition worsened after induced labor despite great effective anti-infective therapy. CNS-IRIS was considered. Corticosteroids were administered, and the patient gradually recovered. We present the first case of CNS-IRIS associated with bacterial meningitis. Frontiers Media S.A. 2021-03-29 /pmc/articles/PMC8044765/ /pubmed/33868222 http://dx.doi.org/10.3389/fimmu.2021.585316 Text en Copyright © 2021 Hu, Liu, Lu, Zhong, Yu, Qiu, Lu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hu, Mengyan
Liu, Sanxin
Lu, Danli
Zhong, Yi
Yu, Dafan
Qiu, Wei
Lu, Zhengqi
Zhang, Bingjun
Case Report: Central Nervous System Immune Reconstitution Inflammatory Syndrome Related to Bacterial Meningitis
title Case Report: Central Nervous System Immune Reconstitution Inflammatory Syndrome Related to Bacterial Meningitis
title_full Case Report: Central Nervous System Immune Reconstitution Inflammatory Syndrome Related to Bacterial Meningitis
title_fullStr Case Report: Central Nervous System Immune Reconstitution Inflammatory Syndrome Related to Bacterial Meningitis
title_full_unstemmed Case Report: Central Nervous System Immune Reconstitution Inflammatory Syndrome Related to Bacterial Meningitis
title_short Case Report: Central Nervous System Immune Reconstitution Inflammatory Syndrome Related to Bacterial Meningitis
title_sort case report: central nervous system immune reconstitution inflammatory syndrome related to bacterial meningitis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044765/
https://www.ncbi.nlm.nih.gov/pubmed/33868222
http://dx.doi.org/10.3389/fimmu.2021.585316
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