Cargando…

The Roles of HIF-1α in Radiosensitivity and Radiation-Induced Bystander Effects Under Hypoxia

Radiation-induced bystander effects (RIBE) may have potential implications for radiotherapy, yet the radiobiological impact and underlying mechanisms in hypoxic tumor cells remain to be determined. Using two human tumor cell lines, hepatoma HepG2 cells and glioblastoma T98G cells, the present study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jianghong, Zhang, Yuhong, Mo, Fang, Patel, Gaurang, Butterworth, Karl, Shao, Chunlin, Prise, Kevin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044822/ https://www.ncbi.nlm.nih.gov/pubmed/33869184 http://dx.doi.org/10.3389/fcell.2021.637454

Ejemplares similares

Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α
por: Wang, Meng, et al.
Publicado: (2021)

NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia
por: Yang, Xing-Liang, et al.
Publicado: (2019)

HIF-1α Protects Granulosa Cells From Hypoxia-Induced Apoptosis During Follicular Development by Inducing Autophagy
por: Tang, Zonghao, et al.
Publicado: (2021)

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease
por: Mitroshina, Elena V., et al.
Publicado: (2021)

HIF1α stabilization in hypoxia is not oxidant-initiated
por: Kumar, Amit, et al.
Publicado: (2021)

HIF-1α Regulates Osteogenesis of Periosteum-Derived Stem Cells Under Hypoxia Conditions via Modulating POSTN Expression
por: Zhuang, Yu, et al.
Publicado: (2022)

HIF1 and ID1 Interplay Confers Adaptive Survival to HIF1α-Inhibition
por: Geng, Hao, et al.
Publicado: (2021)

Culprit or Bystander: Defective Mitophagy in Alzheimer’s Disease
por: Xie, Chenglong, et al.
Publicado: (2020)

Antitumor and Radiosensitization Effects of a CXCR2 Inhibitor in Nasopharyngeal Carcinoma
por: Liu, Xiaobei, et al.
Publicado: (2021)

Exosomes: Innocent Bystanders or Critical Culprits in Neurodegenerative Diseases
por: Beatriz, Margarida, et al.
Publicado: (2021)

Bok: real killer or bystander with non-apoptotic roles?
por: Bonzerato, Caden G., et al.
Publicado: (2023)

Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells
por: Xie, Yuexia, et al.
Publicado: (2016)

Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State
por: Guo, Fei, et al.
Publicado: (2019)

Indispensable Role of HIF-1α Signaling in Post-implantation Survival and Angio-/Vasculogenic Properties of SHED
por: Han, Yuanyuan, et al.
Publicado: (2021)

COX2 Enhances Neovascularization of Inflammatory Tenocytes Through the HIF-1α/VEGFA/PDGFB Pathway
por: Deng, Bin, et al.
Publicado: (2021)

Peroxisome-Deficiency and HIF-2α Signaling Are Negative Regulators of Ketohexokinase Expression
por: Eberhart, Tanja, et al.
Publicado: (2020)

Biological mechanisms of gold nanoparticle radiosensitization
por: Rosa, Soraia, et al.
Publicado: (2017)

Atorvastatin enhances radiosensitivity in hypoxia-induced prostate cancer cells related with HIF-1α inhibition
por: Chen, Bin, et al.
Publicado: (2017)

SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis
por: Yao, Chenguang, et al.
Publicado: (2022)

HIF-1α Directly Controls WNT7A Expression During Myogenesis
por: Cirillo, Federica, et al.
Publicado: (2020)

HIF-1α/BNIP3-Mediated Autophagy Contributes to the Luteinization of Granulosa Cells During the Formation of Corpus Luteum
por: Tang, Zonghao, et al.
Publicado: (2021)

Autophagy regulated by the HIF/REDD1/mTORC1 signaling is progressively increased during erythroid differentiation under hypoxia
por: Li, Jian, et al.
Publicado: (2022)

α-Enolase Lies Downstream of mTOR/HIF1α and Promotes Thyroid Carcinoma Progression by Regulating CST1
por: Liu, Yang, et al.
Publicado: (2021)

Transcription-Based Multidimensional Regulation of Fatty Acid Metabolism by HIF1α in Renal Tubules
por: Li, Wenju, et al.
Publicado: (2021)

Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation
por: Chen, Kaizhe, et al.
Publicado: (2022)

The Role and Mechanism of ATM-Mediated Autophagy in the Transition From Hyper-Radiosensitivity to Induced Radioresistance in Lung Cancer Under Low-Dose Radiation
por: Wang, Qiong, et al.
Publicado: (2021)

Mitophagy Protects the Retina Against Anti-Vascular Endothelial Growth Factor Therapy-Driven Hypoxia via Hypoxia-Inducible Factor-1α Signaling
por: Sun, Yimeng, et al.
Publicado: (2021)

Vitamin D Enhances Radiosensitivity of Colorectal Cancer by Reversing Epithelial-Mesenchymal Transition
por: Yu, Xinyue, et al.
Publicado: (2021)

Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway
por: Tang, Xiaomin, et al.
Publicado: (2021)

The key role of microtubules in hypoxia preconditioning-induced nuclear translocation of HIF-1α in rat cardiomyocytes
por: Guo, Hai, et al.
Publicado: (2017)

HIF1α Regulates IL17 Signaling Pathway Influencing Sensitivity of Taxane-Based Chemotherapy for Breast Cancer
por: Dai, Huijuan, et al.
Publicado: (2021)

The role of hypoxia and radiation in developing a CTCs-like phenotype in murine osteosarcoma cells
por: Quartieri, Martina, et al.
Publicado: (2023)

HIF-1α Affects the Neural Stem Cell Differentiation of Human Induced Pluripotent Stem Cells via MFN2-Mediated Wnt/β-Catenin Signaling
por: Cui, Peng, et al.
Publicado: (2021)

Overcoming of Radioresistance in Non-small Cell Lung Cancer by microRNA-320a Through HIF1α-Suppression Mediated Methylation of PTEN
por: Xu, Li-Ming, et al.
Publicado: (2020)

ANXA6 Contributes to Radioresistance by Promoting Autophagy via Inhibiting the PI3K/AKT/mTOR Signaling Pathway in Nasopharyngeal Carcinoma
por: Chen, Qianping, et al.
Publicado: (2020)

Boosted Radiation Bystander Effect of PSMA-Targeted Gold Nanoparticles in Prostate Cancer Radiosensitization
por: Hara, Daiki, et al.
Publicado: (2022)

An oxygen-insensitive Hif-3α isoform inhibits Wnt signaling by destabilizing the nuclear β-catenin complex
por: Zhang, Peng, et al.
Publicado: (2016)

TGFβ1 in Cancer-Associated Fibroblasts Is Associated With Progression and Radiosensitivity in Small-Cell Lung Cancer
por: Zhang, Jiaqi, et al.
Publicado: (2021)

Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of urothelial cancer and normal urothelial cells
por: Bill, Malgorzata A., et al.
Publicado: (2017)

Exosomes Secreted by Microglia During Virus Infection in the Central Nervous System Activate an Inflammatory Response in Bystander Cells
por: Luong, Nhungoc, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cr6jdrkjuh7p6tusdpceupvi5j