EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice

Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase mediating trimethylation of H3K27, which represses gene expression and is critical to immune regulation. Inhibition of EZH2 is proved to have the potential of treating many diseases. However, whether inhibition of EZH2 affect...

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Detalles Bibliográficos
Autores principales: Wu, Lingling, Jiang, Xiaoyue, Qi, Chaojun, Zhang, Chunyan, Qu, Bo, Shen, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044841/
https://www.ncbi.nlm.nih.gov/pubmed/33868295
http://dx.doi.org/10.3389/fimmu.2021.653989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044841/
https://www.ncbi.nlm.nih.gov/pubmed/33868295
http://dx.doi.org/10.3389/fimmu.2021.653989

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