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RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy

RRM2B plays a crucial role in DNA replication, repair and oxidative stress. While germline RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer has not been established. Here, using TCGA studies, we investigated RRM2B alterations in cancer. We found that RRM2B is...

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Detalles Bibliográficos
Autores principales:	Iqbal, Waleed, Demidova, Elena V., Serrao, Samantha, ValizadehAslani, Taha, Rosen, Gail, Arora, Sanjeevani
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045241/ https://www.ncbi.nlm.nih.gov/pubmed/33868369 http://dx.doi.org/10.3389/fgene.2021.628758

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