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Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

BACKGROUND: Ribonucleases (RNases) play central roles in the post-transcriptional regulation of mRNA stability. Our preliminary results revealed that the endonuclease Regnase-1 is specifically upregulated in osteoarthritic chondrocytes. We herein explored the possible functions and regulatory mechan...

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Detalles Bibliográficos
Autores principales:	Yang, Jeong-In, Chun, Jang-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045248/ https://www.ncbi.nlm.nih.gov/pubmed/33853646 http://dx.doi.org/10.1186/s13075-021-02485-z

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