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Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets

BACKGROUND: The ability of a high level of dietary Arthrospira platensis, individually or in combination with two exogenous carbohydrate-degrading enzymes (lysozyme and Rovabio(®)), to improve systemic antioxidant potential and hepatic lipid metabolism was tested in piglets. Forty male post-weaned p...

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Autores principales: dos Santos Madeira, Marta Sofia Morgado, Lopes, Paula Alexandra Antunes Brás, Martins, Cátia Falcão, Assunção, José Miguel Pestana, Alfaia, Cristina Maria Riscado Pereira Mateus, Pinto, Rui Manuel Amaro, Prates, José António Mestre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045302/
https://www.ncbi.nlm.nih.gov/pubmed/33849543
http://dx.doi.org/10.1186/s12917-021-02869-y
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author dos Santos Madeira, Marta Sofia Morgado
Lopes, Paula Alexandra Antunes Brás
Martins, Cátia Falcão
Assunção, José Miguel Pestana
Alfaia, Cristina Maria Riscado Pereira Mateus
Pinto, Rui Manuel Amaro
Prates, José António Mestre
author_facet dos Santos Madeira, Marta Sofia Morgado
Lopes, Paula Alexandra Antunes Brás
Martins, Cátia Falcão
Assunção, José Miguel Pestana
Alfaia, Cristina Maria Riscado Pereira Mateus
Pinto, Rui Manuel Amaro
Prates, José António Mestre
author_sort dos Santos Madeira, Marta Sofia Morgado
collection PubMed
description BACKGROUND: The ability of a high level of dietary Arthrospira platensis, individually or in combination with two exogenous carbohydrate-degrading enzymes (lysozyme and Rovabio(®)), to improve systemic antioxidant potential and hepatic lipid metabolism was tested in piglets. Forty male post-weaned piglets, sons of Large White × Landrace sows crossed with Pietrain boars, were allocated into 4 groups (n = 10) and fed during 28 days one of the following diets: 1) a control basal diet (cereal and soybean meal); 2) a basal diet with 10% of A. platensis (AP); 3) the AP diet supplemented with 0.005% of Rovabio(®) (AP + R); 4) the AP diet supplemented with 0.01% of lysozyme (AP + L). RESULTS: Arthrospira platensis decreased BW gain of piglets, regardless the addition of feed enzymes. The majority of plasma metabolites were affected by diets. A. platensis increased total lipids, total cholesterol and LDL-cholesterol, without changing hepatic fatty acid content or modulating, in an expressive manner, the transcriptional profile of lipid sensitive mediators. The antioxidant potential in general, and total carotenoids in particular, were improved by the microalga, regardless lysozyme or Rovabio(®). CONCLUSIONS: Summing up, A. platensis, individually and combined with feed enzymes, impacts negatively on piglets’ growth but improves the systemic antioxidant potential and changes plasma lipids with a minor modulation on related hepatic metabolic pathways.
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spelling pubmed-80453022021-04-14 Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets dos Santos Madeira, Marta Sofia Morgado Lopes, Paula Alexandra Antunes Brás Martins, Cátia Falcão Assunção, José Miguel Pestana Alfaia, Cristina Maria Riscado Pereira Mateus Pinto, Rui Manuel Amaro Prates, José António Mestre BMC Vet Res Research Article BACKGROUND: The ability of a high level of dietary Arthrospira platensis, individually or in combination with two exogenous carbohydrate-degrading enzymes (lysozyme and Rovabio(®)), to improve systemic antioxidant potential and hepatic lipid metabolism was tested in piglets. Forty male post-weaned piglets, sons of Large White × Landrace sows crossed with Pietrain boars, were allocated into 4 groups (n = 10) and fed during 28 days one of the following diets: 1) a control basal diet (cereal and soybean meal); 2) a basal diet with 10% of A. platensis (AP); 3) the AP diet supplemented with 0.005% of Rovabio(®) (AP + R); 4) the AP diet supplemented with 0.01% of lysozyme (AP + L). RESULTS: Arthrospira platensis decreased BW gain of piglets, regardless the addition of feed enzymes. The majority of plasma metabolites were affected by diets. A. platensis increased total lipids, total cholesterol and LDL-cholesterol, without changing hepatic fatty acid content or modulating, in an expressive manner, the transcriptional profile of lipid sensitive mediators. The antioxidant potential in general, and total carotenoids in particular, were improved by the microalga, regardless lysozyme or Rovabio(®). CONCLUSIONS: Summing up, A. platensis, individually and combined with feed enzymes, impacts negatively on piglets’ growth but improves the systemic antioxidant potential and changes plasma lipids with a minor modulation on related hepatic metabolic pathways. BioMed Central 2021-04-13 /pmc/articles/PMC8045302/ /pubmed/33849543 http://dx.doi.org/10.1186/s12917-021-02869-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
dos Santos Madeira, Marta Sofia Morgado
Lopes, Paula Alexandra Antunes Brás
Martins, Cátia Falcão
Assunção, José Miguel Pestana
Alfaia, Cristina Maria Riscado Pereira Mateus
Pinto, Rui Manuel Amaro
Prates, José António Mestre
Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets
title Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets
title_full Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets
title_fullStr Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets
title_full_unstemmed Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets
title_short Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets
title_sort dietary arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045302/
https://www.ncbi.nlm.nih.gov/pubmed/33849543
http://dx.doi.org/10.1186/s12917-021-02869-y
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