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Compartments and Connections Within the Germinal Center

Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. I...

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Detalles Bibliográficos
Autores principales: Kennedy, Domenick E., Clark, Marcus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045557/
https://www.ncbi.nlm.nih.gov/pubmed/33868306
http://dx.doi.org/10.3389/fimmu.2021.659151
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author Kennedy, Domenick E.
Clark, Marcus R.
author_facet Kennedy, Domenick E.
Clark, Marcus R.
author_sort Kennedy, Domenick E.
collection PubMed
description Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases.
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spelling pubmed-80455572021-04-15 Compartments and Connections Within the Germinal Center Kennedy, Domenick E. Clark, Marcus R. Front Immunol Immunology Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases. Frontiers Media S.A. 2021-03-31 /pmc/articles/PMC8045557/ /pubmed/33868306 http://dx.doi.org/10.3389/fimmu.2021.659151 Text en Copyright © 2021 Kennedy and Clark https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kennedy, Domenick E.
Clark, Marcus R.
Compartments and Connections Within the Germinal Center
title Compartments and Connections Within the Germinal Center
title_full Compartments and Connections Within the Germinal Center
title_fullStr Compartments and Connections Within the Germinal Center
title_full_unstemmed Compartments and Connections Within the Germinal Center
title_short Compartments and Connections Within the Germinal Center
title_sort compartments and connections within the germinal center
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045557/
https://www.ncbi.nlm.nih.gov/pubmed/33868306
http://dx.doi.org/10.3389/fimmu.2021.659151
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