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Compartments and Connections Within the Germinal Center
Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. I...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045557/ https://www.ncbi.nlm.nih.gov/pubmed/33868306 http://dx.doi.org/10.3389/fimmu.2021.659151 |
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author | Kennedy, Domenick E. Clark, Marcus R. |
author_facet | Kennedy, Domenick E. Clark, Marcus R. |
author_sort | Kennedy, Domenick E. |
collection | PubMed |
description | Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases. |
format | Online Article Text |
id | pubmed-8045557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80455572021-04-15 Compartments and Connections Within the Germinal Center Kennedy, Domenick E. Clark, Marcus R. Front Immunol Immunology Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases. Frontiers Media S.A. 2021-03-31 /pmc/articles/PMC8045557/ /pubmed/33868306 http://dx.doi.org/10.3389/fimmu.2021.659151 Text en Copyright © 2021 Kennedy and Clark https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Kennedy, Domenick E. Clark, Marcus R. Compartments and Connections Within the Germinal Center |
title | Compartments and Connections Within the Germinal Center |
title_full | Compartments and Connections Within the Germinal Center |
title_fullStr | Compartments and Connections Within the Germinal Center |
title_full_unstemmed | Compartments and Connections Within the Germinal Center |
title_short | Compartments and Connections Within the Germinal Center |
title_sort | compartments and connections within the germinal center |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045557/ https://www.ncbi.nlm.nih.gov/pubmed/33868306 http://dx.doi.org/10.3389/fimmu.2021.659151 |
work_keys_str_mv | AT kennedydomenicke compartmentsandconnectionswithinthegerminalcenter AT clarkmarcusr compartmentsandconnectionswithinthegerminalcenter |