Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique

We present a case of a patient in Mozambique, who initiated treatment for rifampicin-resistant tuberculosis (RR-TB) without proof of resistance. For this patient, we estimated the probability of RR-TB using likelihood ratios of clinical arguments. The probability of RR-TB in Mozambique, positive HIV...

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Detalles Bibliográficos
Autores principales: Gonzaga, Lorena D. M., Gils, Tinne, Decroo, Tom, Jacobs, Bart K. M., Lynen, Lutgarde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045612/
https://www.ncbi.nlm.nih.gov/pubmed/33556043
http://dx.doi.org/10.4269/ajtmh.20-0959
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author Gonzaga, Lorena D. M.
Gils, Tinne
Decroo, Tom
Jacobs, Bart K. M.
Lynen, Lutgarde
author_facet Gonzaga, Lorena D. M.
Gils, Tinne
Decroo, Tom
Jacobs, Bart K. M.
Lynen, Lutgarde
author_sort Gonzaga, Lorena D. M.
collection PubMed
description We present a case of a patient in Mozambique, who initiated treatment for rifampicin-resistant tuberculosis (RR-TB) without proof of resistance. For this patient, we estimated the probability of RR-TB using likelihood ratios of clinical arguments. The probability of RR-TB in Mozambique, positive HIV status, and treatment failure after a first treatment and after retreatment were included as confirming arguments, and a rapid molecular test showing rifampicin susceptibility as excluding argument. The therapeutic threshold to start treatment for RR-TB is unknown, but probably lower than 47% and should be calculated to guide clinical decisions.
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spelling pubmed-80456122021-04-19 Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique Gonzaga, Lorena D. M. Gils, Tinne Decroo, Tom Jacobs, Bart K. M. Lynen, Lutgarde Am J Trop Med Hyg Articles We present a case of a patient in Mozambique, who initiated treatment for rifampicin-resistant tuberculosis (RR-TB) without proof of resistance. For this patient, we estimated the probability of RR-TB using likelihood ratios of clinical arguments. The probability of RR-TB in Mozambique, positive HIV status, and treatment failure after a first treatment and after retreatment were included as confirming arguments, and a rapid molecular test showing rifampicin susceptibility as excluding argument. The therapeutic threshold to start treatment for RR-TB is unknown, but probably lower than 47% and should be calculated to guide clinical decisions. The American Society of Tropical Medicine and Hygiene 2021-04 2021-02-08 /pmc/articles/PMC8045612/ /pubmed/33556043 http://dx.doi.org/10.4269/ajtmh.20-0959 Text en © The American Society of Tropical Medicine and Hygiene https://creativecommons.org/licenses/by-nc/4.0/Open Access statement. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.
spellingShingle Articles
Gonzaga, Lorena D. M.
Gils, Tinne
Decroo, Tom
Jacobs, Bart K. M.
Lynen, Lutgarde
Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique
title Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique
title_full Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique
title_fullStr Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique
title_full_unstemmed Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique
title_short Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique
title_sort case report: therapeutic threshold for rifampicin-resistant tuberculosis in a patient from maputo, mozambique
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045612/
https://www.ncbi.nlm.nih.gov/pubmed/33556043
http://dx.doi.org/10.4269/ajtmh.20-0959
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