In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis

Current treatments of visceral leishmaniasis face limitations due to drug side effects and/or high cost, along with the emergence of parasite resistance. Novel and low-cost antileishmanial agents are therefore required. We report herein the antileishmanial activity of β-acetyl-digitoxin (b-AD), a ca...

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Detalles Bibliográficos
Autores principales: Freitas, Camila S., Lage, Daniela P., Oliveira-da-Silva, João A., Costa, Rafaella R., Mendonça, Débora V.C., Martins, Vívian T., Reis, Thiago A.R., Antinarelli, Luciana M.R., Machado, Amanda S., Tavares, Grasiele S.V., Ramos, Fernanda F., Brito, Rory C.F., Ludolf, Fernanda, Chávez-Fumagalli, Miguel A., Roatt, Bruno M., Ramos, Gabriela S., Munkert, Jennifer, Ottoni, Flaviano M., Campana, Priscilla R.V., Duarte, Mariana C., Gonçalves, Denise U., Coimbra, Elaine S., Braga, Fernão C., Pádua, Rodrigo M., Coelho, Eduardo A.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EDP Sciences 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045677/
https://www.ncbi.nlm.nih.gov/pubmed/33851916
http://dx.doi.org/10.1051/parasite/2021036

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