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Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms

Mutations of the Drosophila melanogaster insulin/IGF signaling system slow aging, while also affecting growth and reproduction. To understand this pleiotropy, we produced an allelic series of single codon substitutions in the Drosophila insulin receptor, InR. We generated InR substitutions using hom...

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Detalles Bibliográficos
Autores principales:	Yamamoto, Rochele, Palmer, Michael, Koski, Helen, Curtis-Joseph, Noelle, Tatar, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045697/ https://www.ncbi.nlm.nih.gov/pubmed/33724413 http://dx.doi.org/10.1093/genetics/iyaa037

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