Discovering and Characterizing of Survivin Dominant Negative Mutants With Stronger Pro-apoptotic Activity on Cancer Cells and CSCs

Survivin as a member of the inhibitor of apoptosis proteins (IAPs) family is undetectable in normal cells, but highly expressed in cancer cells and cancer stem cells (CSCs) which makes it an attractive target in cancer therapy. Survivin dominant negative mutants have been reported as competitive inh...

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Detalles Bibliográficos
Autores principales: Guo, Wei, Ma, Xingyuan, Fu, Yunhui, Liu, Chang, Liu, Qiuli, Hu, Fabiao, Miao, Hui, Zhang, Tong, Liu, Yuping, Han, Myong Hun, You, Fang, Yang, Yi, Zheng, Wenyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045750/
https://www.ncbi.nlm.nih.gov/pubmed/33869021
http://dx.doi.org/10.3389/fonc.2021.635233

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