Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes

Ovarian cancer (OV) has become the most lethal gynecological cancer. However, its treatment methods and staging system are far from ideal. In the present study, taking the advantage of large-scale public cohorts, we extracted a list of immune-related prognostic genes that differentially expressed in...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Wu, Qianqian, Wang, Ziheng, Ren, Shiqi, Shen, Hanyu, Shi, Wenyu, Xu, Yunzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045757/
https://www.ncbi.nlm.nih.gov/pubmed/33869044
http://dx.doi.org/10.3389/fonc.2021.647273
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author Wang, Wei
Wu, Qianqian
Wang, Ziheng
Ren, Shiqi
Shen, Hanyu
Shi, Wenyu
Xu, Yunzhao
author_facet Wang, Wei
Wu, Qianqian
Wang, Ziheng
Ren, Shiqi
Shen, Hanyu
Shi, Wenyu
Xu, Yunzhao
author_sort Wang, Wei
collection PubMed
description Ovarian cancer (OV) has become the most lethal gynecological cancer. However, its treatment methods and staging system are far from ideal. In the present study, taking the advantage of large-scale public cohorts, we extracted a list of immune-related prognostic genes that differentially expressed in tumor and normal ovarian tissues. Importantly, an individualized immune-related gene based prognostic model (IPM) for OV patients were developed. Furthermore, we validated our IPM in Gene Expression Omnibus (GEO) repository and compared the immune landscape and pathways between high-risk and low-risk groups. The results of our study can serve as an important model to identify the immune subset of patients and has potential for use in immune therapeutic selection and patient management.
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spelling pubmed-80457572021-04-15 Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes Wang, Wei Wu, Qianqian Wang, Ziheng Ren, Shiqi Shen, Hanyu Shi, Wenyu Xu, Yunzhao Front Oncol Oncology Ovarian cancer (OV) has become the most lethal gynecological cancer. However, its treatment methods and staging system are far from ideal. In the present study, taking the advantage of large-scale public cohorts, we extracted a list of immune-related prognostic genes that differentially expressed in tumor and normal ovarian tissues. Importantly, an individualized immune-related gene based prognostic model (IPM) for OV patients were developed. Furthermore, we validated our IPM in Gene Expression Omnibus (GEO) repository and compared the immune landscape and pathways between high-risk and low-risk groups. The results of our study can serve as an important model to identify the immune subset of patients and has potential for use in immune therapeutic selection and patient management. Frontiers Media S.A. 2021-03-31 /pmc/articles/PMC8045757/ /pubmed/33869044 http://dx.doi.org/10.3389/fonc.2021.647273 Text en Copyright © 2021 Wang, Wu, Wang, Ren, Shen, Shi and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Wei
Wu, Qianqian
Wang, Ziheng
Ren, Shiqi
Shen, Hanyu
Shi, Wenyu
Xu, Yunzhao
Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes
title Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes
title_full Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes
title_fullStr Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes
title_full_unstemmed Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes
title_short Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes
title_sort development of a prognostic model for ovarian cancer patients based on novel immune microenvironment related genes
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045757/
https://www.ncbi.nlm.nih.gov/pubmed/33869044
http://dx.doi.org/10.3389/fonc.2021.647273
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