The Metabolic Landscape of RAS-Driven Cancers from biology to therapy

Our understanding of how the RAS protein family, and in particular mutant KRAS promote metabolic dysregulation in cancer cells has advanced significantly over the last decade. In this Review, we discuss the metabolic reprogramming mediated by oncogenic RAS in cancer, and elucidating the underlying m...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Suman, Vander Heiden, Matthew G., McCormick, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045781/
https://www.ncbi.nlm.nih.gov/pubmed/33870211
http://dx.doi.org/10.1038/s43018-021-00184-x
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author Mukhopadhyay, Suman
Vander Heiden, Matthew G.
McCormick, Frank
author_facet Mukhopadhyay, Suman
Vander Heiden, Matthew G.
McCormick, Frank
author_sort Mukhopadhyay, Suman
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description Our understanding of how the RAS protein family, and in particular mutant KRAS promote metabolic dysregulation in cancer cells has advanced significantly over the last decade. In this Review, we discuss the metabolic reprogramming mediated by oncogenic RAS in cancer, and elucidating the underlying mechanisms could translate to novel therapeutic opportunities to target metabolic vulnerabilities in RAS-driven cancers.
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spelling pubmed-80457812021-09-01 The Metabolic Landscape of RAS-Driven Cancers from biology to therapy Mukhopadhyay, Suman Vander Heiden, Matthew G. McCormick, Frank Nat Cancer Article Our understanding of how the RAS protein family, and in particular mutant KRAS promote metabolic dysregulation in cancer cells has advanced significantly over the last decade. In this Review, we discuss the metabolic reprogramming mediated by oncogenic RAS in cancer, and elucidating the underlying mechanisms could translate to novel therapeutic opportunities to target metabolic vulnerabilities in RAS-driven cancers. 2021-03-24 2021-03 /pmc/articles/PMC8045781/ /pubmed/33870211 http://dx.doi.org/10.1038/s43018-021-00184-x Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Mukhopadhyay, Suman
Vander Heiden, Matthew G.
McCormick, Frank
The Metabolic Landscape of RAS-Driven Cancers from biology to therapy
title The Metabolic Landscape of RAS-Driven Cancers from biology to therapy
title_full The Metabolic Landscape of RAS-Driven Cancers from biology to therapy
title_fullStr The Metabolic Landscape of RAS-Driven Cancers from biology to therapy
title_full_unstemmed The Metabolic Landscape of RAS-Driven Cancers from biology to therapy
title_short The Metabolic Landscape of RAS-Driven Cancers from biology to therapy
title_sort metabolic landscape of ras-driven cancers from biology to therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045781/
https://www.ncbi.nlm.nih.gov/pubmed/33870211
http://dx.doi.org/10.1038/s43018-021-00184-x
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