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Variability of white matter anatomy in the subcallosal cingulate area

The subcallosal cingulate (SCC) area is a putative hub in the brain network underlying depression. Deep brain stimulation (DBS) targeting a particular subregion of SCC, identified as the intersection of forceps minor (FM), uncinate fasciculus (UCF), cingulum and fronto‐striatal fiber bundles, may be...

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Detalles Bibliográficos
Autores principales: Tsolaki, Evangelia, Sheth, Sameer A., Pouratian, Nader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046077/
https://www.ncbi.nlm.nih.gov/pubmed/33484503
http://dx.doi.org/10.1002/hbm.25341
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author Tsolaki, Evangelia
Sheth, Sameer A.
Pouratian, Nader
author_facet Tsolaki, Evangelia
Sheth, Sameer A.
Pouratian, Nader
author_sort Tsolaki, Evangelia
collection PubMed
description The subcallosal cingulate (SCC) area is a putative hub in the brain network underlying depression. Deep brain stimulation (DBS) targeting a particular subregion of SCC, identified as the intersection of forceps minor (FM), uncinate fasciculus (UCF), cingulum and fronto‐striatal fiber bundles, may be critical to a therapeutic response in patients with severe, treatment‐resistant forms of major depressive disorder (MDD). The pattern and variability of the white matter anatomy and organization within SCC has not been extensively characterized across individuals. The goal of this study is to investigate the variability of white matter bundles within the SCC that structurally connect this region with critical nodes in the depression network. Structural and diffusion data from 100 healthy subjects from the Human Connectome Project database were analyzed. Anatomically defined SCC regions were used as seeds to perform probabilistic tractography and to estimate the connectivity from the SCC to subject‐specific target areas believed to be involved in the pathology of MDD including ventral striatum (VS), UCF, anterior cingulate cortex (ACC), and medial prefrontal cortex (mPFC). Four distinct areas of connectivity were identified within SCC across subjects: (a) postero‐lateral SCC connectivity to medial temporal regions via UCF, (b) postero‐medial connectivity to VS, (c) superior‐medial connectivity to ACC via cingulum bundle, and (d) antero‐lateral connectivity to mPFC regions via forceps minor. Assuming white matter connectivity is critical to therapeutic response, the improved anatomic understanding of SCC as well as an appreciation of the intersubject variability are critical to developing optimized therapeutic targeting for SCC DBS.
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spelling pubmed-80460772021-04-16 Variability of white matter anatomy in the subcallosal cingulate area Tsolaki, Evangelia Sheth, Sameer A. Pouratian, Nader Hum Brain Mapp Research Articles The subcallosal cingulate (SCC) area is a putative hub in the brain network underlying depression. Deep brain stimulation (DBS) targeting a particular subregion of SCC, identified as the intersection of forceps minor (FM), uncinate fasciculus (UCF), cingulum and fronto‐striatal fiber bundles, may be critical to a therapeutic response in patients with severe, treatment‐resistant forms of major depressive disorder (MDD). The pattern and variability of the white matter anatomy and organization within SCC has not been extensively characterized across individuals. The goal of this study is to investigate the variability of white matter bundles within the SCC that structurally connect this region with critical nodes in the depression network. Structural and diffusion data from 100 healthy subjects from the Human Connectome Project database were analyzed. Anatomically defined SCC regions were used as seeds to perform probabilistic tractography and to estimate the connectivity from the SCC to subject‐specific target areas believed to be involved in the pathology of MDD including ventral striatum (VS), UCF, anterior cingulate cortex (ACC), and medial prefrontal cortex (mPFC). Four distinct areas of connectivity were identified within SCC across subjects: (a) postero‐lateral SCC connectivity to medial temporal regions via UCF, (b) postero‐medial connectivity to VS, (c) superior‐medial connectivity to ACC via cingulum bundle, and (d) antero‐lateral connectivity to mPFC regions via forceps minor. Assuming white matter connectivity is critical to therapeutic response, the improved anatomic understanding of SCC as well as an appreciation of the intersubject variability are critical to developing optimized therapeutic targeting for SCC DBS. John Wiley & Sons, Inc. 2021-01-23 /pmc/articles/PMC8046077/ /pubmed/33484503 http://dx.doi.org/10.1002/hbm.25341 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Tsolaki, Evangelia
Sheth, Sameer A.
Pouratian, Nader
Variability of white matter anatomy in the subcallosal cingulate area
title Variability of white matter anatomy in the subcallosal cingulate area
title_full Variability of white matter anatomy in the subcallosal cingulate area
title_fullStr Variability of white matter anatomy in the subcallosal cingulate area
title_full_unstemmed Variability of white matter anatomy in the subcallosal cingulate area
title_short Variability of white matter anatomy in the subcallosal cingulate area
title_sort variability of white matter anatomy in the subcallosal cingulate area
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046077/
https://www.ncbi.nlm.nih.gov/pubmed/33484503
http://dx.doi.org/10.1002/hbm.25341
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