Cargando…

Structural control energy of resting‐state functional brain states reveals less cost‐effective brain dynamics in psychosis vulnerability

How the brain's white‐matter anatomy constrains brain activity is an open question that might give insights into the mechanisms that underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder with an extremely high risk for p...

Descripción completa

Detalles Bibliográficos
Autores principales: Zöller, Daniela, Sandini, Corrado, Schaer, Marie, Eliez, Stephan, Bassett, Danielle S., Van De Ville, Dimitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046160/
https://www.ncbi.nlm.nih.gov/pubmed/33566395
http://dx.doi.org/10.1002/hbm.25358
_version_ 1783678796284559360
author Zöller, Daniela
Sandini, Corrado
Schaer, Marie
Eliez, Stephan
Bassett, Danielle S.
Van De Ville, Dimitri
author_facet Zöller, Daniela
Sandini, Corrado
Schaer, Marie
Eliez, Stephan
Bassett, Danielle S.
Van De Ville, Dimitri
author_sort Zöller, Daniela
collection PubMed
description How the brain's white‐matter anatomy constrains brain activity is an open question that might give insights into the mechanisms that underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder with an extremely high risk for psychosis providing a test case to study developmental aspects of schizophrenia. In this study, we used principles from network control theory to probe the implications of aberrant structural connectivity for the brain's functional dynamics in 22q11DS. We retrieved brain states from resting‐state functional magnetic resonance images of 78 patients with 22q11DS and 85 healthy controls. Then, we compared them in terms of persistence control energy; that is, the control energy that would be required to persist in each of these states based on individual structural connectivity and a dynamic model. Persistence control energy was altered in a broad pattern of brain states including both energetically more demanding and less demanding brain states in 22q11DS. Further, we found a negative relationship between persistence control energy and resting‐state activation time, which suggests that the brain reduces energy by spending less time in energetically demanding brain states. In patients with 22q11DS, this behavior was less pronounced, suggesting a deficiency in the ability to reduce energy through brain activation. In summary, our results provide initial insights into the functional implications of altered structural connectivity in 22q11DS, which might improve our understanding of the mechanisms underlying the disease.
format Online
Article
Text
id pubmed-8046160
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-80461602021-04-16 Structural control energy of resting‐state functional brain states reveals less cost‐effective brain dynamics in psychosis vulnerability Zöller, Daniela Sandini, Corrado Schaer, Marie Eliez, Stephan Bassett, Danielle S. Van De Ville, Dimitri Hum Brain Mapp Research Articles How the brain's white‐matter anatomy constrains brain activity is an open question that might give insights into the mechanisms that underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder with an extremely high risk for psychosis providing a test case to study developmental aspects of schizophrenia. In this study, we used principles from network control theory to probe the implications of aberrant structural connectivity for the brain's functional dynamics in 22q11DS. We retrieved brain states from resting‐state functional magnetic resonance images of 78 patients with 22q11DS and 85 healthy controls. Then, we compared them in terms of persistence control energy; that is, the control energy that would be required to persist in each of these states based on individual structural connectivity and a dynamic model. Persistence control energy was altered in a broad pattern of brain states including both energetically more demanding and less demanding brain states in 22q11DS. Further, we found a negative relationship between persistence control energy and resting‐state activation time, which suggests that the brain reduces energy by spending less time in energetically demanding brain states. In patients with 22q11DS, this behavior was less pronounced, suggesting a deficiency in the ability to reduce energy through brain activation. In summary, our results provide initial insights into the functional implications of altered structural connectivity in 22q11DS, which might improve our understanding of the mechanisms underlying the disease. John Wiley & Sons, Inc. 2021-02-10 /pmc/articles/PMC8046160/ /pubmed/33566395 http://dx.doi.org/10.1002/hbm.25358 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Zöller, Daniela
Sandini, Corrado
Schaer, Marie
Eliez, Stephan
Bassett, Danielle S.
Van De Ville, Dimitri
Structural control energy of resting‐state functional brain states reveals less cost‐effective brain dynamics in psychosis vulnerability
title Structural control energy of resting‐state functional brain states reveals less cost‐effective brain dynamics in psychosis vulnerability
title_full Structural control energy of resting‐state functional brain states reveals less cost‐effective brain dynamics in psychosis vulnerability
title_fullStr Structural control energy of resting‐state functional brain states reveals less cost‐effective brain dynamics in psychosis vulnerability
title_full_unstemmed Structural control energy of resting‐state functional brain states reveals less cost‐effective brain dynamics in psychosis vulnerability
title_short Structural control energy of resting‐state functional brain states reveals less cost‐effective brain dynamics in psychosis vulnerability
title_sort structural control energy of resting‐state functional brain states reveals less cost‐effective brain dynamics in psychosis vulnerability
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046160/
https://www.ncbi.nlm.nih.gov/pubmed/33566395
http://dx.doi.org/10.1002/hbm.25358
work_keys_str_mv AT zollerdaniela structuralcontrolenergyofrestingstatefunctionalbrainstatesrevealslesscosteffectivebraindynamicsinpsychosisvulnerability
AT sandinicorrado structuralcontrolenergyofrestingstatefunctionalbrainstatesrevealslesscosteffectivebraindynamicsinpsychosisvulnerability
AT schaermarie structuralcontrolenergyofrestingstatefunctionalbrainstatesrevealslesscosteffectivebraindynamicsinpsychosisvulnerability
AT eliezstephan structuralcontrolenergyofrestingstatefunctionalbrainstatesrevealslesscosteffectivebraindynamicsinpsychosisvulnerability
AT bassettdanielles structuralcontrolenergyofrestingstatefunctionalbrainstatesrevealslesscosteffectivebraindynamicsinpsychosisvulnerability
AT vandevilledimitri structuralcontrolenergyofrestingstatefunctionalbrainstatesrevealslesscosteffectivebraindynamicsinpsychosisvulnerability