Discovery and Protein Modeling Studies of Novel Compound Mutations Causing Resistance to Multiple Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

OBJECTIVE: BCR-ABL fusion oncogene is the hallmark of chronic myeloid leukemia (CML), causing genomic instability which leads to accumulation of mutations in BCR-ABL as well as other genes. BCR-ABL mutations are the cause of tyrosine kinase inhibitors (TKIs) resistance in CML. Recently, compound BCR...

Descripción completa

Detalles Bibliográficos
Autores principales: Iqbal, Zafar, Absar, Muhammad, Mahmood, Amer, Aleem, Aamer, Iqbal, Mudassar, Jameel, Abid, Akhtar, Tanveer, Karim, Sajjad, Rasool, Mahmood, Mirza, Zeenat, Khalid, Muhammad, Akram, Afia Muhammad, Sabar, Muhammad Farooq, Khalid, Ahmad M, Aljarrah, Khalid, Iqbal, Janhangir, Shah, Ijaz H, Alanazi, Nawaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046299/
https://www.ncbi.nlm.nih.gov/pubmed/33369447
http://dx.doi.org/10.31557/APJCP.2020.21.12.3517

Ejemplares similares

Ejemplares similares