Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity

Human Polycomb Repressive Complex 2 (PRC2) catalysis of histone H3 lysine 27 methylation at certain loci depends on long noncoding RNAs (lncRNAs). Yet, in apparent contradiction, RNA is a potent catalytic inhibitor of PRC2. Here, we show that intermolecular RNA-RNA interactions between the lncRNA HO...

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Detalles Bibliográficos
Autores principales: Balas, Maggie M., Hartwick, Erik W., Barrington, Chloe, Roberts, Justin T., Wu, Stephen K., Bettcher, Ryan, Griffin, April M., Kieft, Jeffrey S., Johnson, Aaron M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046370/
https://www.ncbi.nlm.nih.gov/pubmed/33853770
http://dx.doi.org/10.1126/sciadv.abc9191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046370/
https://www.ncbi.nlm.nih.gov/pubmed/33853770
http://dx.doi.org/10.1126/sciadv.abc9191

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