Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza

Infection of certain influenza viruses is triggered when its HA is cleaved by host cell proteases such as proprotein convertases and type II transmembrane serine proteases (TTSP). HA with a monobasic motif is cleaved by trypsin-like proteases, including TMPRSS2 and HAT, whereas the multibasic motif...

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Detalles Bibliográficos
Autores principales: Ohno, Ayako, Maita, Nobuo, Tabata, Takanori, Nagano, Hikaru, Arita, Kyohei, Ariyoshi, Mariko, Uchida, Takayuki, Nakao, Reiko, Ulla, Anayt, Sugiura, Kosuke, Kishimoto, Koji, Teshima-Kondo, Shigetada, Okumura, Yuushi, Nikawa, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046417/
https://www.ncbi.nlm.nih.gov/pubmed/33820827
http://dx.doi.org/10.26508/lsa.202000849

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