Cargando…

Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19

Inflammation is an essential component of several respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome (ARDS). It is central to lung cancer, the leading cancer in terms of associated mortality that has affected millions of individ...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmad, Shama, Manzoor, Shajer, Siddiqui, Simmone, Mariappan, Nithya, Zafar, Iram, Ahmad, Aamir, Ahmad, Aftab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046427/
https://www.ncbi.nlm.nih.gov/pubmed/33484868
http://dx.doi.org/10.1016/j.semcancer.2021.01.003
_version_ 1783678847380619264
author Ahmad, Shama
Manzoor, Shajer
Siddiqui, Simmone
Mariappan, Nithya
Zafar, Iram
Ahmad, Aamir
Ahmad, Aftab
author_facet Ahmad, Shama
Manzoor, Shajer
Siddiqui, Simmone
Mariappan, Nithya
Zafar, Iram
Ahmad, Aamir
Ahmad, Aftab
author_sort Ahmad, Shama
collection PubMed
description Inflammation is an essential component of several respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome (ARDS). It is central to lung cancer, the leading cancer in terms of associated mortality that has affected millions of individuals worldwide. Inflammation and pulmonary manifestations are also the major causes of COVID-19 related deaths. Acute hyperinflammation plays an important role in the COVID-19 disease progression and severity, and development of protective immunity against the virus is greatly sought. Further, the severity of COVID-19 is greatly enhanced in lung cancer patients, probably due to the genes such as ACE2, TMPRSS2, PAI-1 and furin that are commonly involved in cancer progression as well as SAR-CoV-2 infection. The importance of inflammation in pulmonary manifestations, cancer and COVID-19 calls for a closer look at the underlying processes, particularly the associated increase in IL-6 and other cytokines, the dysregulation of immune cells and the coagulation pathway. Towards this end, several reports have identified epigenetic regulation of inflammation at different levels. Expression of several key inflammation-related cytokines, chemokines and other genes is affected by methylation and acetylation while non-coding RNAs, including microRNAs as well as long non-coding RNAs, also affect the overall inflammatory responses. Select miRNAs can regulate inflammation in COVID-19 infection, lung cancer as well as other inflammatory lung diseases, and can serve as epigenetic links that can be therapeutically targeted. Furthermore, epigenetic changes also mediate the environmental factors-induced inflammation. Therefore, a better understanding of epigenetic regulation of inflammation can potentially help develop novel strategies to prevent, diagnose and treat chronic pulmonary diseases, lung cancer and COVID-19.
format Online
Article
Text
id pubmed-8046427
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-80464272021-04-15 Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19 Ahmad, Shama Manzoor, Shajer Siddiqui, Simmone Mariappan, Nithya Zafar, Iram Ahmad, Aamir Ahmad, Aftab Semin Cancer Biol Article Inflammation is an essential component of several respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome (ARDS). It is central to lung cancer, the leading cancer in terms of associated mortality that has affected millions of individuals worldwide. Inflammation and pulmonary manifestations are also the major causes of COVID-19 related deaths. Acute hyperinflammation plays an important role in the COVID-19 disease progression and severity, and development of protective immunity against the virus is greatly sought. Further, the severity of COVID-19 is greatly enhanced in lung cancer patients, probably due to the genes such as ACE2, TMPRSS2, PAI-1 and furin that are commonly involved in cancer progression as well as SAR-CoV-2 infection. The importance of inflammation in pulmonary manifestations, cancer and COVID-19 calls for a closer look at the underlying processes, particularly the associated increase in IL-6 and other cytokines, the dysregulation of immune cells and the coagulation pathway. Towards this end, several reports have identified epigenetic regulation of inflammation at different levels. Expression of several key inflammation-related cytokines, chemokines and other genes is affected by methylation and acetylation while non-coding RNAs, including microRNAs as well as long non-coding RNAs, also affect the overall inflammatory responses. Select miRNAs can regulate inflammation in COVID-19 infection, lung cancer as well as other inflammatory lung diseases, and can serve as epigenetic links that can be therapeutically targeted. Furthermore, epigenetic changes also mediate the environmental factors-induced inflammation. Therefore, a better understanding of epigenetic regulation of inflammation can potentially help develop novel strategies to prevent, diagnose and treat chronic pulmonary diseases, lung cancer and COVID-19. Elsevier Ltd. 2022-08 2021-01-20 /pmc/articles/PMC8046427/ /pubmed/33484868 http://dx.doi.org/10.1016/j.semcancer.2021.01.003 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ahmad, Shama
Manzoor, Shajer
Siddiqui, Simmone
Mariappan, Nithya
Zafar, Iram
Ahmad, Aamir
Ahmad, Aftab
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19
title Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19
title_full Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19
title_fullStr Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19
title_full_unstemmed Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19
title_short Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19
title_sort epigenetic underpinnings of inflammation: connecting the dots between pulmonary diseases, lung cancer and covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046427/
https://www.ncbi.nlm.nih.gov/pubmed/33484868
http://dx.doi.org/10.1016/j.semcancer.2021.01.003
work_keys_str_mv AT ahmadshama epigeneticunderpinningsofinflammationconnectingthedotsbetweenpulmonarydiseaseslungcancerandcovid19
AT manzoorshajer epigeneticunderpinningsofinflammationconnectingthedotsbetweenpulmonarydiseaseslungcancerandcovid19
AT siddiquisimmone epigeneticunderpinningsofinflammationconnectingthedotsbetweenpulmonarydiseaseslungcancerandcovid19
AT mariappannithya epigeneticunderpinningsofinflammationconnectingthedotsbetweenpulmonarydiseaseslungcancerandcovid19
AT zafariram epigeneticunderpinningsofinflammationconnectingthedotsbetweenpulmonarydiseaseslungcancerandcovid19
AT ahmadaamir epigeneticunderpinningsofinflammationconnectingthedotsbetweenpulmonarydiseaseslungcancerandcovid19
AT ahmadaftab epigeneticunderpinningsofinflammationconnectingthedotsbetweenpulmonarydiseaseslungcancerandcovid19