Cargando…

Paeoniflorin Attenuates Dexamethasone-Induced Apoptosis of Osteoblast Cells and Promotes Bone Formation via Regulating AKT/mTOR/Autophagy Signaling Pathway

Paeoniflorin, a natural product derived from Paeonia lactiflora, possesses diverse pharmacological activities such as anti-inflammatory, antitumor, and antidiabetic effects. It has been reported for promoting osteoblastogenesis and inhibiting osteoclastogenesis. This study investigates the therapeut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Liyu, Liu, Shengye, Mu, Shuai, Guo, Ran, Zhou, Long, Fu, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046541/ https://www.ncbi.nlm.nih.gov/pubmed/33880124 http://dx.doi.org/10.1155/2021/6623464

Ejemplares similares

Paeoniflorin attenuates gestational diabetes via Akt/mTOR pathway in a rat model
por: Zhang, Yonghua, et al.
Publicado: (2020)

Gastrodin protects MC3T3-E1 osteoblasts from dexamethasone-induced cellular dysfunction and promotes bone formation via induction of the NRF2 signaling pathway
por: Liu, Shengye, et al.
Publicado: (2018)

Valproic Acid Enhanced Apoptosis by Promoting Autophagy Via Akt/mTOR Signaling in Glioma
por: Han, Wei, et al.
Publicado: (2020)

Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells
por: Li, Gaopan, et al.
Publicado: (2021)

Leonurine Promotes the Osteoblast Differentiation of Rat BMSCs by Activation of Autophagy via the PI3K/Akt/mTOR Pathway
por: Zhao, Bingkun, et al.
Publicado: (2021)

Apatinib-induced protective autophagy and apoptosis through the AKT–mTOR pathway in anaplastic thyroid cancer
por: Feng, Haoran, et al.
Publicado: (2018)

CWHM-1008 Induces Apoptosis and Protective Autophagy through the Akt/mTOR Axis in LUAD Cells
por: Zhang, Jiao, et al.
Publicado: (2021)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Kaempferol attenuated diabetic nephropathy by reducing apoptosis and promoting autophagy through AMPK/mTOR pathways
por: Sheng, Hongqin, et al.
Publicado: (2022)

Glipizide sensitizes lung cancer cells to TRAIL-induced apoptosis via Akt/mTOR/autophagy pathways
por: Nazim, Uddin MD., et al.
Publicado: (2017)

Matrine induces Akt/mTOR signalling inhibition‐mediated autophagy and apoptosis in acute myeloid leukaemia cells
por: Wu, Junqing, et al.
Publicado: (2016)

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
por: Liu, Xihong, et al.
Publicado: (2019)

Stigmasterol Simultaneously Induces Apoptosis and Protective Autophagy by Inhibiting Akt/mTOR Pathway in Gastric Cancer Cells
por: Zhao, Huange, et al.
Publicado: (2021)

Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway
por: Yuan, Yunfeng, et al.
Publicado: (2021)

Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression
por: Gong, Xuelian, et al.
Publicado: (2021)

Nitidine Chloride Triggers Autophagy and Apoptosis of Ovarian Cancer Cells through Akt/mTOR Signaling Pathway
por: Lian, Chaoqun, et al.
Publicado: (2023)

Regulation of osteoblast autophagy based on PI3K/AKT/mTOR signaling pathway study on the effect of β-ecdysterone on fracture healing
por: Tang, Yanghua, et al.
Publicado: (2021)

Paeoniflorin inhibits proliferation and promotes autophagy and apoptosis of sweat gland cells
por: Xu, Yuan, et al.
Publicado: (2022)

Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway
por: Yu, Wei, et al.
Publicado: (2017)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway
por: Zhou, Jin, et al.
Publicado: (2019)

8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy via the PI3K/Akt/mTOR Signaling Pathway
por: Xue, Yucong, et al.
Publicado: (2021)

β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6
por: Xu, Guang, et al.
Publicado: (2022)

Correction to: Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
por: Liu, Xihong, et al.
Publicado: (2019)

Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis
por: Hong, Pan, et al.
Publicado: (2020)

SPAG5‐AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway
por: Xu, Jun, et al.
Publicado: (2020)

Procyanidin B2 induces apoptosis and autophagy in gastric cancer cells by inhibiting Akt/mTOR signaling pathway
por: Li, Yuqin, et al.
Publicado: (2021)

Hesperetin Induces Autophagy and Delayed Apoptosis by Modulating the AMPK/Akt/mTOR Pathway in Human Leukemia Cells In Vitro
por: Lin, Ching-Yeh, et al.
Publicado: (2023)

Fluorofenidone attenuates paraquat-induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy
por: Jiang, Feiya, et al.
Publicado: (2021)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

AB44. Akt inhibition attenuates rasfonin (A304)-induced autophagy and casapase-dependent apoptosis via mTOR complex signaling in renal cancer cells
por: Xi, Zhijun
Publicado: (2014)

mtROS-mediated Akt/AMPK/mTOR pathway was involved in Copper-induced autophagy and it attenuates Copper-induced apoptosis in RAW264.7 mouse monocytes
por: Luo, Qin, et al.
Publicado: (2021)

Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways
por: Zhao, Zhengbo, et al.
Publicado: (2020)

Arctigenin Inhibits Glioblastoma Proliferation through the AKT/mTOR Pathway and Induces Autophagy
por: Jiang, Yong'an, et al.
Publicado: (2020)

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
por: Liu, Jing, et al.
Publicado: (2019)

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence
por: Strozyk, Elwira, et al.
Publicado: (2013)

Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK
por: Bhattacharjee, Arindam, et al.
Publicado: (2018)

Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway
por: Lin, Yu-Tsai, et al.
Publicado: (2017)

Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway
por: ZHAO, ZHONG-QUAN, et al.
Publicado: (2016)

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways
por: Liu, Xihong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_m9ijvbkf1f6i0np0r1m03n3g46