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Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a multisystemic disease and a rapidly growing cause of chronic liver disease in children and adults worldwide. Diagnosis and management of extrahepatic manifestations of NAFLD, including cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syn...

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Autores principales: Wijarnpreecha, Karn, Aby, Elizabeth S., Ahmed, Aijaz, Kim, Donghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association for the Study of the Liver 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046623/
https://www.ncbi.nlm.nih.gov/pubmed/33317243
http://dx.doi.org/10.3350/cmh.2020.0239
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author Wijarnpreecha, Karn
Aby, Elizabeth S.
Ahmed, Aijaz
Kim, Donghee
author_facet Wijarnpreecha, Karn
Aby, Elizabeth S.
Ahmed, Aijaz
Kim, Donghee
author_sort Wijarnpreecha, Karn
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is a multisystemic disease and a rapidly growing cause of chronic liver disease in children and adults worldwide. Diagnosis and management of extrahepatic manifestations of NAFLD, including cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome, chronic kidney disease, obstructive sleep apnea, polycystic ovarian syndrome, hypothyroidism, psoriasis, and extrahepatic malignancy are crucial for the treatment of patients with NAFLD. The leading cause of death in NAFLD is primarily from CVD, followed by liver-related mortality, extrahepatic cancer, liver cancer, and diabetes-related mortality. Therefore, clinicians need to identify high-risk patients earlier in the disease course and be aware of the extrahepatic manifestations of NAFLD to improve liver disease outcomes. In this review, we focus on the monitoring and management of the extrahepatic manifestations of NAFLD.
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spelling pubmed-80466232021-04-22 Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease Wijarnpreecha, Karn Aby, Elizabeth S. Ahmed, Aijaz Kim, Donghee Clin Mol Hepatol Review Nonalcoholic fatty liver disease (NAFLD) is a multisystemic disease and a rapidly growing cause of chronic liver disease in children and adults worldwide. Diagnosis and management of extrahepatic manifestations of NAFLD, including cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome, chronic kidney disease, obstructive sleep apnea, polycystic ovarian syndrome, hypothyroidism, psoriasis, and extrahepatic malignancy are crucial for the treatment of patients with NAFLD. The leading cause of death in NAFLD is primarily from CVD, followed by liver-related mortality, extrahepatic cancer, liver cancer, and diabetes-related mortality. Therefore, clinicians need to identify high-risk patients earlier in the disease course and be aware of the extrahepatic manifestations of NAFLD to improve liver disease outcomes. In this review, we focus on the monitoring and management of the extrahepatic manifestations of NAFLD. The Korean Association for the Study of the Liver 2021-04 2020-12-03 /pmc/articles/PMC8046623/ /pubmed/33317243 http://dx.doi.org/10.3350/cmh.2020.0239 Text en Copyright © 2021 by The Korean Association for the Study of the Liver https://creativecommons.org/licenses/by-nc/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wijarnpreecha, Karn
Aby, Elizabeth S.
Ahmed, Aijaz
Kim, Donghee
Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease
title Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease
title_full Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease
title_fullStr Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease
title_full_unstemmed Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease
title_short Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease
title_sort evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046623/
https://www.ncbi.nlm.nih.gov/pubmed/33317243
http://dx.doi.org/10.3350/cmh.2020.0239
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