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Does higher body mass index increase COVID-19 severity? A systematic review and meta-analysis
INTRODUCTION: Obesity and higher BMI is one of the leading comorbidities to increase the risk of COVID-19 severity. This paper presents a systematic review and meta-analysis estimating the effects of overweight and obesity on COVID-19 disease severity. METHOD: Two electronic databases (Medline and C...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046705/ https://www.ncbi.nlm.nih.gov/pubmed/33875972 http://dx.doi.org/10.1016/j.obmed.2021.100340 |
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author | Chowdhury, Akibul Islam Alam, Mohammad Rahanur Rabbi, Md. Fazley Rahman, Tanjina Reza, Sompa |
author_facet | Chowdhury, Akibul Islam Alam, Mohammad Rahanur Rabbi, Md. Fazley Rahman, Tanjina Reza, Sompa |
author_sort | Chowdhury, Akibul Islam |
collection | PubMed |
description | INTRODUCTION: Obesity and higher BMI is one of the leading comorbidities to increase the risk of COVID-19 severity. This paper presents a systematic review and meta-analysis estimating the effects of overweight and obesity on COVID-19 disease severity. METHOD: Two electronic databases (Medline and Cochrane library) and one grey literature database (Grey Literature Report) were searched. The risks of bias of the selected studies were assessed by using the Navigation Guide method for human data. Both random and fixed effect meta-analyses were determined using Review Manager (RevMan) software version 5.4. RESULTS: After initial screening, 12 studies were fulfilled the eligibility criteria, comprising a total of 405359 patients, and included in the systematic review. The pooled risk of COVID-19 severity was 1.31 times higher based on both fixed and random effect model among those overweight patients, I(2) 0% and 2.09 and 2.41 times higher based on fixed and random effect respectively among obese patients, I(2) 42% compared to healthy individuals. CONCLUSION: Overweight and obesity are found to be risk factors for disease severity of COVID-19 patients. However, further assessment of metabolic parameters is required to estimate the risk factors of COVID-19 patients and understanding the mechanism between COVID-19 and body mass index. |
format | Online Article Text |
id | pubmed-8046705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80467052021-04-15 Does higher body mass index increase COVID-19 severity? A systematic review and meta-analysis Chowdhury, Akibul Islam Alam, Mohammad Rahanur Rabbi, Md. Fazley Rahman, Tanjina Reza, Sompa Obes Med Article INTRODUCTION: Obesity and higher BMI is one of the leading comorbidities to increase the risk of COVID-19 severity. This paper presents a systematic review and meta-analysis estimating the effects of overweight and obesity on COVID-19 disease severity. METHOD: Two electronic databases (Medline and Cochrane library) and one grey literature database (Grey Literature Report) were searched. The risks of bias of the selected studies were assessed by using the Navigation Guide method for human data. Both random and fixed effect meta-analyses were determined using Review Manager (RevMan) software version 5.4. RESULTS: After initial screening, 12 studies were fulfilled the eligibility criteria, comprising a total of 405359 patients, and included in the systematic review. The pooled risk of COVID-19 severity was 1.31 times higher based on both fixed and random effect model among those overweight patients, I(2) 0% and 2.09 and 2.41 times higher based on fixed and random effect respectively among obese patients, I(2) 42% compared to healthy individuals. CONCLUSION: Overweight and obesity are found to be risk factors for disease severity of COVID-19 patients. However, further assessment of metabolic parameters is required to estimate the risk factors of COVID-19 patients and understanding the mechanism between COVID-19 and body mass index. Elsevier Ltd. 2021-05 2021-04-15 /pmc/articles/PMC8046705/ /pubmed/33875972 http://dx.doi.org/10.1016/j.obmed.2021.100340 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Chowdhury, Akibul Islam Alam, Mohammad Rahanur Rabbi, Md. Fazley Rahman, Tanjina Reza, Sompa Does higher body mass index increase COVID-19 severity? A systematic review and meta-analysis |
title | Does higher body mass index increase COVID-19 severity? A systematic review and meta-analysis |
title_full | Does higher body mass index increase COVID-19 severity? A systematic review and meta-analysis |
title_fullStr | Does higher body mass index increase COVID-19 severity? A systematic review and meta-analysis |
title_full_unstemmed | Does higher body mass index increase COVID-19 severity? A systematic review and meta-analysis |
title_short | Does higher body mass index increase COVID-19 severity? A systematic review and meta-analysis |
title_sort | does higher body mass index increase covid-19 severity? a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046705/ https://www.ncbi.nlm.nih.gov/pubmed/33875972 http://dx.doi.org/10.1016/j.obmed.2021.100340 |
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