Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

Lung cancer is the leading cause of cancer deaths. Tumor heterogeneity, which hampers development of targeted therapies, was herein deconvoluted via single cell RNA sequencing in aggressive human adenocarcinomas (carrying Kras-mutations) and comparable murine model. We identified a tumor-specific, m...

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Detalles Bibliográficos
Autores principales: Maroni, Giorgia, Bassal, Mahmoud A., Krishnan, Indira, Fhu, Chee Wai, Savova, Virginia, Zilionis, Rapolas, Maymi, Valerie A., Pandell, Nicole, Csizmadia, Eva, Zhang, Junyan, Storti, Barbara, Castaño, Julio, Panella, Riccardo, Li, Jia, Gustafson, Corinne E., Fox, Sam, Levy, Rachel D., Meyerovitz, Claire V., Tramontozzi, Peter J., Vermilya, Kimberly, De Rienzo, Assunta, Crucitta, Stefania, Bassères, Daniela S., Weetall, Marla, Branstrom, Art, Giorgetti, Alessandra, Ciampi, Raffaele, Del Re, Marzia, Danesi, Romano, Bizzarri, Ranieri, Yang, Henry, Kocher, Olivier, Klein, Allon M., Welner, Robert S., Bueno, Raphael, Magli, Maria Cristina, Clohessy, John G., Ali, Azhar, Tenen, Daniel G., Levantini, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046784/
https://www.ncbi.nlm.nih.gov/pubmed/33854168
http://dx.doi.org/10.1038/s42003-021-01897-6

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