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Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation
A radiological or nuclear attack could involve such a large number of subjects as to overwhelm the emergency facilities in charge. Resources should therefore be focused on those subjects needing immediate medical attention and care. In such a scenario, for the triage management by first responders,...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047015/ https://www.ncbi.nlm.nih.gov/pubmed/33854097 http://dx.doi.org/10.1038/s41598-021-87173-3 |
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author | Giovanetti, Anna Marconi, Raffaella Awad, Noha Abuzied, Hala Agamy, Neveen Barakat, Mohamed Bartoleschi, Cecilia Bossi, Gianluca Canfora, Marco Elsaid, Amr A. Ioannilli, Laura Ismail, Horeya M. Issa, Yasmine Amr Novelli, Flavia Pardini, Maria Chiara Pioli, Claudio Pinnarò, Paola Sanguineti, Giuseppe Tahoun, Mohamed M. Turchi, Riccardo Strigari, Lidia |
author_facet | Giovanetti, Anna Marconi, Raffaella Awad, Noha Abuzied, Hala Agamy, Neveen Barakat, Mohamed Bartoleschi, Cecilia Bossi, Gianluca Canfora, Marco Elsaid, Amr A. Ioannilli, Laura Ismail, Horeya M. Issa, Yasmine Amr Novelli, Flavia Pardini, Maria Chiara Pioli, Claudio Pinnarò, Paola Sanguineti, Giuseppe Tahoun, Mohamed M. Turchi, Riccardo Strigari, Lidia |
author_sort | Giovanetti, Anna |
collection | PubMed |
description | A radiological or nuclear attack could involve such a large number of subjects as to overwhelm the emergency facilities in charge. Resources should therefore be focused on those subjects needing immediate medical attention and care. In such a scenario, for the triage management by first responders, it is necessary to count on efficient biological dosimetry tools capable of early detection of the absorbed dose. At present the validated assays for measuring the absorbed dose are dicentric chromosomes and micronuclei counts, which require more than 2–3 days to obtain results. To overcome this limitation the NATO SPS Programme funded an Italian–Egyptian collaborative project aimed at validating a fast, accurate and feasible tool for assessing the absorbed dose early after radiation exposure. Biomarkers as complete blood cell counts, DNA breaks and radio-inducible proteins were investigated on blood samples collected before and 3 h after the first fraction of radiotherapy in patients treated in specific target areas with doses/fraction of about: 2, 3.5 or > 5 Gy and compared with the reference micronuclei count. Based on univariate and multivariate multiple linear regression correlation, our results identify five early biomarkers potentially useful for detecting the extent of the absorbed dose 3 h after the exposure. |
format | Online Article Text |
id | pubmed-8047015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80470152021-04-15 Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation Giovanetti, Anna Marconi, Raffaella Awad, Noha Abuzied, Hala Agamy, Neveen Barakat, Mohamed Bartoleschi, Cecilia Bossi, Gianluca Canfora, Marco Elsaid, Amr A. Ioannilli, Laura Ismail, Horeya M. Issa, Yasmine Amr Novelli, Flavia Pardini, Maria Chiara Pioli, Claudio Pinnarò, Paola Sanguineti, Giuseppe Tahoun, Mohamed M. Turchi, Riccardo Strigari, Lidia Sci Rep Article A radiological or nuclear attack could involve such a large number of subjects as to overwhelm the emergency facilities in charge. Resources should therefore be focused on those subjects needing immediate medical attention and care. In such a scenario, for the triage management by first responders, it is necessary to count on efficient biological dosimetry tools capable of early detection of the absorbed dose. At present the validated assays for measuring the absorbed dose are dicentric chromosomes and micronuclei counts, which require more than 2–3 days to obtain results. To overcome this limitation the NATO SPS Programme funded an Italian–Egyptian collaborative project aimed at validating a fast, accurate and feasible tool for assessing the absorbed dose early after radiation exposure. Biomarkers as complete blood cell counts, DNA breaks and radio-inducible proteins were investigated on blood samples collected before and 3 h after the first fraction of radiotherapy in patients treated in specific target areas with doses/fraction of about: 2, 3.5 or > 5 Gy and compared with the reference micronuclei count. Based on univariate and multivariate multiple linear regression correlation, our results identify five early biomarkers potentially useful for detecting the extent of the absorbed dose 3 h after the exposure. Nature Publishing Group UK 2021-04-14 /pmc/articles/PMC8047015/ /pubmed/33854097 http://dx.doi.org/10.1038/s41598-021-87173-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Giovanetti, Anna Marconi, Raffaella Awad, Noha Abuzied, Hala Agamy, Neveen Barakat, Mohamed Bartoleschi, Cecilia Bossi, Gianluca Canfora, Marco Elsaid, Amr A. Ioannilli, Laura Ismail, Horeya M. Issa, Yasmine Amr Novelli, Flavia Pardini, Maria Chiara Pioli, Claudio Pinnarò, Paola Sanguineti, Giuseppe Tahoun, Mohamed M. Turchi, Riccardo Strigari, Lidia Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation |
title | Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation |
title_full | Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation |
title_fullStr | Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation |
title_full_unstemmed | Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation |
title_short | Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation |
title_sort | validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047015/ https://www.ncbi.nlm.nih.gov/pubmed/33854097 http://dx.doi.org/10.1038/s41598-021-87173-3 |
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