A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis

Caspase-11, a cytosolic lipopolysaccharide (LPS) receptor, mediates lethal immune responses and coagulopathy in sepsis, a leading cause of death worldwide with limited therapeutic options. We previously showed that over-activation of caspase-11 is driven by hepatocyte-released high mobility group bo...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiangyu, Li, Zhaozheng, Bai, Yang, Zhang, Rui, Meng, Ran, Chen, Fangping, Wang, Haichao, Billiar, Timothy R., Xiao, Xianzhong, Lu, Ben, Tang, Yiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047024/
https://www.ncbi.nlm.nih.gov/pubmed/33854044
http://dx.doi.org/10.1038/s41419-021-03652-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047024/
https://www.ncbi.nlm.nih.gov/pubmed/33854044
http://dx.doi.org/10.1038/s41419-021-03652-5

Ejemplares similares